A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Esophagus

    July 2021 in “ Frontiers in Cell and Developmental Biology ”
    Diana Pereira, Inês Sequeira
    Studysummary This review examines the regeneration capabilities of skin, oesophagus, and oral mucosa, highlighting the oral mucosa's unique scarless healing properties and the potential of cell therapy to improve scar reduction in wound healing.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on frontiersin.org →
    Discuss this study in the Community →

    Research cited in this study 38

    1. Defining the Transcriptional Signature of Esophageal-to-Skin Lineage Conversion bioRxiv (Cold Spring Harbor Laboratory) · 2021
    2. Single-Cell Transcriptomic Analysis of Small and Large Wounds Reveals the Distinct Spatial Organization of Regenerative Fibroblasts Experimental Dermatology · 2020
    3. Distinct Regulatory Programs Control the Latent Regenerative Potential of Dermal Fibroblasts During Wound Healing Cell stem cell · 2020
    4. Toward Understanding Scarless Skin Wound Healing and Pathological Scarring F1000Research · 2019
    5. The Spectrum of Scarring in Craniofacial Wound Repair Frontiers in Physiology · 2019
    6. Single-Cell Analysis Reveals Fibroblast Heterogeneity and Myeloid-Derived Adipocyte Progenitors in Murine Skin Wounds Nature Communications · 2019
    7. Stem Cell Dynamics, Migration, and Plasticity During Wound Healing Nature Cell Biology · 2018
    8. Defining Skin Fibroblastic Cell Types Beyond CD90 Frontiers in Cell and Developmental Biology · 2018
    9. Lineage Identity and Location Within the Dermis Determine the Function of Papillary and Reticular Fibroblasts in Human Skin Journal of Investigative Dermatology · 2018
    10. Fibroblast State Switching Orchestrates Dermal Maturation and Wound Healing Molecular Systems Biology · 2018
    11. Signaling in the Stem Cell Niche: Regulating Cell Fate, Function, and Plasticity Development · 2018
    12. SFRP2/DPP4 and FMO1/LSP1 Define Major Fibroblast Populations in Human Skin Journal of Investigative Dermatology · 2018
    13. Spatial and Single-Cell Transcriptional Profiling Identifies Functionally Distinct Human Dermal Fibroblast Subpopulations Journal of Investigative Dermatology · 2018
    14. Skin Wound Healing in Humans and Mice: Challenges in Translational Research Journal of Dermatological Science · 2017
    15. In Vitro Models to Study Hair Follicle Generation Elsevier eBooks · 2017
    16. Wounding Induces Dedifferentiation of Epidermal Gata6+ Cells and Acquisition of Stem Cell Properties Nature cell biology · 2017
    17. Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices Cell · 2017
    18. Multifaceted Role of Hair Follicle Dermal Cells in Bioengineered Skins British journal of dermatology/British journal of dermatology, Supplement · 2016
    19. Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions Advances in wound care · 2016
    20. Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages Nature Communications · 2016
    21. Inhibition of β-Catenin Signaling in Dermal Fibroblasts Enhances Hair Follicle Regeneration During Wound Healing Development · 2016
    22. The Dynamic Duo: Niche and Stem Cell Interdependency Stem Cell Reports · 2015
    23. Keratins and Skin Disease: Genetic and Molecular Roles Cell & tissue research/Cell and tissue research · 2015
    24. Plasticity of Epithelial Stem Cells in Tissue Regeneration Science · 2014
    25. Adipocytes in Skin Health and Disease Cold Spring Harbor Perspectives in Medicine · 2014
    26. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    27. Structure and Function of Skin, Hair, and Nails Medicine · 2013
    28. Identification of Stem Cell Populations in Sweat Glands and Ducts Reveals Roles in Homeostasis and Wound Repair Cell · 2012
    29. Microenvironmental Reprogramming of Thymic Epithelial Cells to Skin Multipotent Stem Cells Nature · 2010
    30. Wound Repair at a Glance Journal of Cell Science · 2009
    31. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    32. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    33. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    34. Scratching the Surface of Skin Development Nature · 2007
    35. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    36. Mammalian Fetal Organ Regeneration Advances in Biochemical Engineering / Biotechnology · 2005
    37. Dermal-Epidermal Interactions in Hair Follicle Development and Maintenance Dermatologic clinics · 1996
    38. Inductive Properties of Hair Follicle Cells Annals of the New York Academy of Sciences · 1991