A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Esophagus

    July 2021 in “ Frontiers in Cell and Developmental Biology ”
    Diana Pereira, Inês Sequeira
    TLDR Oral mucosa heals with minimal scarring, offering insights for scarless wound healing.
    The review compared the healing processes and cellular architecture of skin, oral mucosa, and oesophagus, highlighting the oral mucosa's exceptional regenerative potential and scarless healing properties. It found that oral mucosa fibroblasts, similar to fetal skin, exhibited enhanced migratory capacity and resistance to scarring, unlike skin fibroblasts which led to scar formation. The study emphasized the role of epithelial-stromal interactions and keratin expression differences in tissue homeostasis and healing. Oral mucosa's unique environment, reduced inflammation, and faster keratinocyte proliferation contributed to its scarless healing. The document also explored the potential of tissue-engineered oral mucosa (TEOM) for regenerative therapies, suggesting its advantages over skin cells due to its scarless healing capabilities, and highlighted its applications in various tissue repairs, including skin and esophageal healing.
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