A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Esophagus

    July 2021 in “ Frontiers in Cell and Developmental Biology ”
    Diana Pereira, Inês Sequeira
    TLDR Oral mucosa heals with minimal scarring, offering insights for scarless wound healing.
    This review examined the differences in wound healing and regeneration between the skin, oesophagus, and oral mucosa, highlighting the oral mucosa's exceptional ability to heal with minimal scarring. It discussed the roles of epithelial stem cells and fibroblast subpopulations in tissue regeneration. The review also explored recent studies that combined cell therapy with bioengineering to leverage the oral mucosa's unique scarless healing properties to enhance skin and oesophageal wound healing and reduce fibrosis. These findings suggested potential pathways toward achieving scarless wound healing.
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