TLDR Nude mice with grafted human skin developed scars similar to human hypertrophic scars.
The study demonstrated that grafting split-thickness human skin onto nude mice resulted in scars that were morphologically, histologically, and immunohistochemically consistent with human hypertrophic scars (HSc). Twenty nude mice were xenografted and observed up to 180 days, showing characteristics such as increased thickness, loss of hair follicles, hypercellularity, and specific collagen fiber patterns. This model provided a promising technique for studying HSc formation and testing new treatments.
86 citations,
October 2005 in “Experimental Dermatology” The Foxn1 gene mutation causes hairlessness and immune system issues, and understanding it could lead to hair growth disorder treatments.
August 2023 in “International Journal of Molecular Sciences” Human skin xenografting could improve our understanding of skin development, renewal, and healing.
32 citations,
December 2015 in “PloS one” P144® improves hypertrophic scars by reducing size and thickness and increasing elasticity.
1 citations,
January 2016 in “Elsevier eBooks” The document concludes that a complete skin restoration biomaterial does not yet exist, and more clinical trials are needed to ensure these therapies are safe and effective.
142 citations,
March 2019 in “Molecules/Molecules online/Molecules annual” Cannabinoids may help treat various skin conditions.
43 citations,
July 2019 in “Stem Cells International” Advancements in creating skin grafts with biomaterials and stem cells are promising, but more research is needed for clinical application.
