A Nude Mouse Model of Hypertrophic Scar Shows Morphologic and Histologic Characteristics of Human Hypertrophic Scar

    November 2012 in “ Wound repair and regeneration ”
    Moein Momtazi, Peter Kwan, Jie Ding, Colin C. Anderson, Dariush Honardoust, Serge Goekjian, Edward E. Tredget
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    TLDR Nude mice with grafted human skin developed scars similar to human hypertrophic scars.
    The study demonstrated that grafting split-thickness human skin onto nude mice resulted in scars that were morphologically, histologically, and immunohistochemically consistent with human hypertrophic scars (HSc). Twenty nude mice were xenografted and observed up to 180 days, showing characteristics such as increased thickness, loss of hair follicles, hypercellularity, and specific collagen fiber patterns. This model provided a promising technique for studying HSc formation and testing new treatments.
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