NIR-Responsive Multifunctional Artificial Skin for Regenerative Wound Healing

May 2024 in “ Advanced Functional Materials ”

Yiyue Hong, Mengyang Wang, De Jin Hu, Yujia Wang, Shuaifei Ji, Jiangbing Xiang, Hongliang Zhang, Huating Chen, Yan Li, Mingchen Xiong, Wei Pi, Qianyi Wang, Xinling Yang, Yingying Li, Chaochen Shui, Xiaolei Wang, Xiaobing Fu, Xiao-hong Sun

TLDR The artificial skin promotes better wound healing and skin regeneration.

The study presents a multifunctional artificial skin (NIR‐mFAS) designed to enhance regenerative wound healing for full-thickness wounds. This artificial skin uses a chitosan/silk fibroin hydrogel matrix to encapsulate and release epidermal growth factor (EGF), promoting cell migration and proliferation for re-epithelialization and neovascularization. Polydopamine nanoparticles (PDA‐NPs) within the matrix enable controlled release of BMP4 under 1064 nm NIR irradiation, reducing scarring by decreasing myofibroblasts. Additionally, the controlled release of CHIR99021 induces the conversion of myofibroblasts into dermal papilla-like cells, facilitating hair follicle and sebaceous gland regeneration. This system offers a smart therapeutic approach for high-quality wound healing with skin appendage regeneration.

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research The Roles of WNT Signaling Pathways in Skin Development and Mechanical-Stretch-Induced Skin Regeneration

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research Dermal Papilla Cell-Derived Exosomes Regulate Hair Follicle Stem Cell Proliferation via LEF1

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Exosomes from skin cells can boost hair growth by stimulating a gene called LEF1.

research A Drug-Free, Hair Follicle Cycling Regulatable, Separable, Antibacterial Microneedle Patch for Hair Regeneration Therapy

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research Wnt/β-Catenin Signaling: Function, Biological Mechanisms, and Therapeutic Opportunities

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research KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis

13 citations, May 2021 in “British Journal of Pharmacology”

KY19382 helps regrow hair and create new hair follicles.

Induction of Dermal Fibroblasts into Dermal Papilla Cell-Like Cells in Hydrogel Microcapsules for Enhanced Hair Follicle Regeneration

research Induction of Dermal Fibroblasts into Dermal Papilla Cell-Like Cells in Hydrogel Microcapsules for Enhanced Hair Follicle Regeneration

4 citations, December 2020 in “Applied Materials Today”

Hydrogel microcapsules help create cells that boost hair growth.

research Activating an Adaptive Immune Response from a Hydrogel Scaffold Imparts Regenerative Wound Healing

328 citations, November 2020 in “Nature Materials”

Hydrogel scaffolds can help wounds heal better and grow hair.

research Dermal Exosomes Containing miR-218-5p Promote Hair Regeneration by Regulating β-Catenin Signaling

65 citations, July 2020 in “Science Advances”

Dermal exosomes with miR-218-5p boost hair growth by controlling β-catenin signaling.

research Wound Healing: A Cellular Perspective

1160 citations, January 2019 in “Physiological Reviews”

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.