NIR-Responsive Multifunctional Artificial Skin for Regenerative Wound Healing
May 2024
in “
Advanced Functional Materials
”
NIR‐mFAS chitosan silk fibroin hydrogel epidermal growth factor EGF cell migration cell proliferation re-epithelialization neovascularization polydopamine nanoparticles PDA‐NPs BMP4 NIR irradiation myofibroblasts CHIR99021 dermal papilla-like cells hair follicle regeneration sebaceous gland regeneration NIR-responsive artificial skin silk fibroin dermal papilla cells
TLDR The artificial skin promotes better wound healing and skin regeneration.
The study presents a multifunctional artificial skin (NIR-mFAS) designed to enhance the regenerative potential of full-thickness wounds. This artificial skin utilizes a chitosan/silk fibroin hydrogel matrix to encapsulate and sustain the release of epidermal growth factor (EGF), promoting cell migration and proliferation for improved re-epithelialization and neovascularization. The inclusion of photothermal responsive polydopamine nanoparticles allows for precise control over the release of BMP4, reducing scarring by inhibiting myofibroblasts. Additionally, the controlled release of CHIR99021 facilitates the conversion of myofibroblasts into dermal papilla-like cells, promoting hair follicle and sebaceous gland regeneration. This innovative system offers a smart therapeutic approach for high-quality wound healing with appendage regeneration, potentially applicable to other treatments requiring coordinated delivery of multiple pharmacological agents.
