NIR-Responsive Multifunctional Artificial Skin for Regenerative Wound Healing

    May 2024 in “ Advanced Functional Materials ”
    Yiyue Hong, Mengyang Wang, De Jin Hu, Yujia Wang, Shuaifei Ji, Jiangbing Xiang, Hongliang Zhang, Huating Chen, Yan Li, Mingchen Xiong, Wei Pi, Qianyi Wang, Xinling Yang, Yingying Li, Chaochen Shui, Xiaolei Wang, Xiaobing Fu, Xiao-hong Sun
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    TLDR The artificial skin promotes better wound healing and skin regeneration.
    The study presents a multifunctional artificial skin (NIR‐mFAS) designed to enhance regenerative wound healing for full-thickness wounds. This artificial skin uses a chitosan/silk fibroin hydrogel matrix to encapsulate and release epidermal growth factor (EGF), promoting cell migration and proliferation for re-epithelialization and neovascularization. Polydopamine nanoparticles (PDA‐NPs) within the matrix enable controlled release of BMP4 under 1064 nm NIR irradiation, reducing scarring by decreasing myofibroblasts. Additionally, the controlled release of CHIR99021 induces the conversion of myofibroblasts into dermal papilla-like cells, facilitating hair follicle and sebaceous gland regeneration. This system offers a smart therapeutic approach for high-quality wound healing with skin appendage regeneration.
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