A Volar Skin Excisional Wound Model for In Situ Evaluation of Multiple-Appendage Regeneration and Innervation

    January 2023 in “ Burns & Trauma ”
    Huanhuan Gao, Y. Liu, Ziwei Shi, Hongliang Zhang, Mengyang Wang, Huating Chen, Yan Li, Shaoping Ji, Jiangbing Xiang, Wei Pi, Laixian Zhou, Yiyue Hong, Wei Lü, Aizhen Cai, Xiaobing Fu, Xiaoyan Sun
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    Studysummary This study introduced a volar skin excisional wound model that closely mirrors human wound healing and supports evaluation of skin regeneration with multiple appendages and innervation. Our plain-language summary of this paper — not a Tressless recommendation.
    The study developed a volar skin excisional wound model (VEWM) using 40 C57BL/6 mice to examine cutaneous wound healing, multiple-appendage restoration, and innervation. The VEWM closely mimics the healing process of human wounds, with wound areas at 1, 3, 7, and 10 days after operation being 89.17%, 71.72%, 55.09%, and 35.74% respectively, and the final scar area accounting for 47.80% of the initial wound. The volar skin of the mice, richly innervated and comprising hair follicles, sebaceous glands, and sweat glands, was studied. Hair growth was limited to the inter-footpad area, with 67.23 hairs on average. The number of sweat glands in footpads and inter-footpads was 77.25 and 3.95 respectively. The study concluded that the VEWM can be used for skin multiple-appendages regeneration and innervation evaluation.
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