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This study introduced a volar skin excisional wound model that closely mirrors human wound healing and supports evaluation of skin regeneration with multiple appendages and innervation.

This study reports that a new artificial skin system using multi-layered hydrogels can promote scarless wound healing and regenerate appendages like hair follicles without cell transplantation.

This research re-analyzed single-cell gene expression data from a mouse model, confirming that certain genes involved in the EDA-EDAR and WNT pathways are crucial for skin appendage development, suggesting that their restoration may mitigate the effects of hypohidrotic ectodermal dysplasia in children.

This review discusses recent advancements in generating appendage-bearing skin organoids from pluripotent stem cells and their potential applications in dermatological research, but reports no new clinical results.

This article reviews current strategies and advancements in regenerating skin appendages and sensory nerves in tissue-engineered skin, highlighting the challenge of restoring skin sensations like pain, temperature, and touch to improve patients’ quality of life.