Interplay Between EDA-EDAR and WNT Signaling Pathways in the Development of Skin Appendages in Hypohidrotic Ectodermal Dysplasia

    April 2025 in “ Pediatria i Medycyna Rodzinna ”
    Ajay Jakhar, Konrad Łukaszyk, Anna Puławska-Czub, Krzysztof Kobielak
    Studysummary This research re-analyzed single-cell gene expression data from a mouse model, confirming that certain genes involved in the EDA-EDAR and WNT pathways are crucial for skin appendage development, suggesting that their restoration may mitigate the effects of hypohidrotic ectodermal dysplasia in children.
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    4. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    5. WNT10A Mutation Causes Ectodermal Dysplasia by Impairing Progenitor Cell Proliferation and KLF4-Mediated Differentiation Nature Communications · 2017
    6. Competitive Balance of Intrabulge BMP/Wnt Signaling Reveals a Robust Gene Network Ruling Stem Cell Homeostasis and Cyclic Activation Proceedings of the National Academy of Sciences · 2013
    7. Adenovirus-Mediated Wnt5a Expression Inhibits the Telogen-To-Anagen Transition of Hair Follicles in Mice International journal of medical sciences · 2013
    8. Dermal β-Catenin Activity in Response to Epidermal Wnt Ligands Is Required for Fibroblast Proliferation and Hair Follicle Initiation Development · 2012
    9. Identification of Dkk4 as a Target of Eda-A1/Edar Pathway Reveals an Unexpected Role of Ectodysplasin as Inhibitor of Wnt Signaling in Ectodermal Placodes Developmental biology · 2008
    10. The Wnt Inhibitor, Dickkopf 4, Is Induced by Canonical Wnt Signaling During Ectodermal Appendage Morphogenesis Developmental biology · 2007

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