Engineered Nanovesicles from Fibroblasts Modulate Dermal Papillae Cells In Vitro and Promote Human Hair Follicle Growth Ex Vivo

The study explores the potential of engineered nanovesicles (eNVs) derived from fibroblasts to promote hair growth by modulating dermal papilla (DP) cells. Tested on human DP cells and hair follicles from 3 participants, eNVs significantly increased DP cell proliferation and migration, particularly at specific concentrations. They also enhanced hair shaft elongation in ex vivo cultures. The presence of proteins like VEGF-a in eNVs activated pathways that increased proliferation markers and signaling pathways in DP cells. These findings suggest that eNVs could be a promising therapeutic approach for treating hair loss conditions.