Differential Distribution and Genetic Determination of Eccrine Sweat Glands and Hair Follicles in the Volar Skin of C57BL/6 Mice and SD Rats
August 2022
in “
BMC Veterinary Research
”
TLDR C57BL/6 mice and SD rats have different sweat gland and hair follicle patterns, useful for skin research.
The study examined the distribution and genetic determination of eccrine sweat glands (ESGs) and hair follicles (HFs) in the volar skin of C57BL/6 mice and SD rats. It found that ESGs were present in the footpads of both species, but HFs were absent. In the inter-footpads (IFPs), C57BL/6 mice had both ESGs and HFs, while SD rats had neither. The expression of the gene En1 was linked to ESG distribution, and LHX2 to HF distribution. The study concluded that these distribution patterns should inform the choice of animal models for research on skin appendage development, wound healing, and regeneration, with C57BL/6 mice being more suitable for studies involving both ESGs and HFs.
