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GlossarySprague-Dawley rats

albino rats commonly used in laboratory research

Sprague-Dawley rats are a breed of albino rats commonly used in laboratory research due to their docile nature, ease of handling, and well-documented genetic background. They are frequently employed in studies related to toxicology, pharmacology, and various biological and medical research areas, including hair and skin studies, due to their consistent and reproducible responses.

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research Sub-Chronic Testosterone Treatment Increases the Levels of Epithelial Sodium Channel (ENaC)-α, β, and γ in the Kidney of Orchidectomized Adult Male Sprague–Dawley Rats

18 citations , June 2016 in “PeerJ”

Testosterone increases certain kidney protein levels, potentially raising blood pressure.

research Hair Regenerative Activities of Flavonoid-Rich Extract of Equisetum Hyemale in Chemically-Induced Alopecia in Sprague Dawley Rats

1 citations , January 2019 in “Journal of pharmacy & pharmacognosy research”

The flavonoid-rich extract of Equisetum hyemale can help regrow hair in cases of alopecia.

Inhibitory Effects of Pueraria Mirifica Aqueous Extracts on 5α-Reductase and Prostate Histomorphometry in Testosterone-Induced Benign Prostatic Hyperplasia Sprague Dawley Rats

research Inhibitory Effects of Pueraria Mirifica Aqueous Extracts on 5α-Reductase and Prostate Histomorphometry in Testosterone-Induced Benign Prostatic Hyperplasia Sprague Dawley Rats

August 2023 in “Malaysian Journal of Medicine and Health Sciences/Malaysian journal of medicine and health sciences”

Pueraria mirifica extract may help treat benign prostatic hyperplasia.

Supraphysiological Dose of Testosterone Impairs the Expression and Distribution of Sex Steroid Receptors During Endometrial Receptivity Development in Female Sprague-Dawley Rats

research Supraphysiological Dose of Testosterone Impairs the Expression and Distribution of Sex Steroid Receptors During Endometrial Receptivity Development in Female Sprague-Dawley Rats

September 2024 in “International Journal of Molecular Sciences”

High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.

research Reversible Decreases of Fertility in Male Sprague-Dawley Rats Treated Orally with Finasteride, a 5α-Reductase Inhibitor

28 citations , January 1991 in “Reproductive Toxicology”

Finasteride temporarily lowers male rat fertility without affecting libido.

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community Brief summary of new dutasteride study linked to infertility and the limitations/problems with the study

in Finasteride/Dutasteride 34 upvotes 7 months ago

Dutasteride treatment may decrease sperm concentration, but levels remain above WHO recommendations and recover after discontinuation. The study has limitations, including small sample size and lack of pre-treatment sperm data, and does not assess other fertility factors.