🚨 The study involves hormones that affect human hair, such as testosterone, and mentions finasteride, a treatment for hair loss, but focuses on endometrial receptivity rather than hair or scalp health.
TLDR High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.
This study on female Sprague–Dawley rats (n=24) found that a supraphysiological dose of testosterone significantly reduced oestrogen and progesterone levels, increased androgen receptor mRNA expression, and decreased progesterone and oestrogen receptor-α expression. Immunohistochemistry confirmed these findings, showing that high testosterone levels disrupt the implantation window by altering sex steroid receptor distribution and expression, which impairs endometrial receptivity. The addition of finasteride and anastrozole did not significantly mitigate these effects, indicating the primary role of high testosterone levels in these disruptions.
October 2022 in “Biomedicines” Finasteride in male rats causes liver and metabolic issues in their offspring.
5 citations,
January 2020 in “in Vivo” Testosterone changes important cell communication proteins in pregnant rats' uteruses, which might affect pregnancy success.
[object Object] 
10 citations,
December 2019 in “in Vivo” Testosterone makes the connections in the uterus lining simpler and lowers certain protein levels, which might lead to infertility.
38 citations,
September 2019 in “Chinese Medical Journal” Using steroids can increase the risk of heart problems.
55 citations,
May 2019 in “Journal of Endocrinology” Androgens are important for female fertility and could help in IVF treatment, but also play a role in causing PCOS.
120 citations,
April 2019 in “The Journal of clinical investigation/The journal of clinical investigation” Both estrogens and androgens are important for health in both males and females.
[object Object] 
37 citations,
February 2013 in “Maturitas” Testosterone therapy is beneficial for women's health and does not cause masculinization or liver damage, and it protects the heart and breasts.
20 citations,
May 2011 in “Cancer Biology & Therapy” Finasteride may improve prostate cancer treatment outcomes.
9 citations,
July 2021 in “Essays in Biochemistry” Sex hormones may influence COVID-19 severity, with males at higher risk, and certain hormone therapies could potentially treat the virus.
658 citations,
June 2003 in “Endocrine reviews” Male hormones may play a role in the development of heart disease, and more research is needed to understand their effects.
93 citations,
June 2001 in “The Journal of Clinical Endocrinology and Metabolism” Certain genetic variations in the AR and ERβ genes can affect androgen levels in women.
[object Object] 
68 citations,
April 2014 in “Journal of Molecular Endocrinology” The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.
4 citations,
October 2007 in “Dermatologic Clinics” Glucocorticoids and sex hormones affect skin health, with potential for targeted treatments to minimize side effects and treat skin conditions.
