Supraphysiological Dose of Testosterone Impairs the Expression and Distribution of Sex Steroid Receptors During Endometrial Receptivity Development in Female Sprague-Dawley Rats

    Allia Najmie Muhammad Yusuf, Mohd Fariz Amri, Azizah Ugusman … Mohd Helmy Mokhtar
    🚨 The study involves hormones that affect human hair, such as testosterone, and mentions finasteride, a treatment for hair loss, but focuses on endometrial receptivity rather than hair or scalp health.
    Studysummary This study found that administering a supraphysiological dose of testosterone to female rats significantly reduced estrogen and progesterone levels, disrupted sex steroid receptor expression, and interfered with the embryonic implantation window, indicating potential implications for androgen-related endometrial conditions.
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    Research cited in this study 8

    1. The Interplay Between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation Biomedicines · 2022
    2. Effects of Testosterone on the Expression of Connexin 26 and Connexin 43 in the Uterus of Rats During Early Pregnancy in Vivo · 2020
    3. Testosterone Reduces Tight Junction Complexity and Down-Regulates Expression of Claudin-4 and Occludin in the Endometrium in Ovariectomized, Sex-Steroid Replacement Rats in Vivo · 2019
    4. Anabolic-Androgenic Steroids and Cardiovascular Risk Chinese Medical Journal · 2019
    5. Androgens and Ovarian Function: Translation from Basic Discovery Research to Clinical Impact Journal of Endocrinology · 2019
    6. Impact of Estrogens in Males and Androgens in Females ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2019
    7. Testosterone Therapy in Women: Myths and Misconceptions Maturitas · 2013
    8. The Antiandrogenic Effect of Finasteride Against a Mutant Androgen Receptor Cancer Biology & Therapy · 2011