Supraphysiological Dose of Testosterone Impairs the Expression and Distribution of Sex Steroid Receptors During Endometrial Receptivity Development in Female Sprague-Dawley Rats

    September 2024 in “ International Journal of Molecular Sciences ”
    Allia Najmie Muhammad Yusuf, Mohd Fariz Amri, Azizah Ugusman, Adila A. Hamid, Mohd Helmy Mokhtar
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    TLDR High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.
    This study investigated the impact of a supraphysiological dose of testosterone on sex steroid hormone levels and receptor expression in the uterus during endometrial receptivity in female Sprague–Dawley rats (n = 24). The results showed that testosterone significantly reduced oestrogen and progesterone levels and altered the expression of sex steroid receptors, with increased androgen receptor mRNA and decreased progesterone and oestrogen receptor-α mRNA. These changes disrupted the implantation window, suggesting that testosterone plays a critical role in endometrial receptivity and could inform therapeutic approaches for androgen-mediated disorders.
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