The Interplay Between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation

    October 2022 in “ Biomedicines ”
    Sylwia Rzeszotek, Agnieszka Kolasa, Anna Pilutin … Barbara Wiszniewska
    Studysummary In this rat study, offspring from females fertilized by finasteride-treated males showed hyperglycemia and increased hepatic glycogen, linking paternal androgen imbalance to liver issues across generations.
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    Research cited in this study 13

    1. Paternal Finasteride Treatment Can Influence the Testicular Transcriptome Profile of Male Offspring—Preliminary Study Current Issues in Molecular Biology · 2021
    2. Differential Gene Expression in Post-Finasteride Syndrome Patients The Journal of Sexual Medicine · 2021
    3. The Postnatal Offspring of Finasteride-Treated Male Rats Shows Hyperglycemia, Elevated Hepatic Glycogen Storage, and Altered GLUT2, IR, and AR Expression in the Liver International Journal of Molecular Sciences · 2021
    4. Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians Fertility and Sterility · 2020
    5. The Post-Finasteride Syndrome: Clinical Manifestation of Drug-Induced Epigenetics Due to Endocrine Disruption Current Sexual Health Reports · 2018
    6. Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway Drug Design Development and Therapy · 2017
    7. The Mechanisms and Functions of Interorganelle Interactions Molecular biology of the cell · 2017
    8. Sexual Side Effects of 5-Alpha-Reductase Inhibitors Finasteride and Dutasteride: A Comprehensive Review Dermatology Online Journal · 2017
    9. Emotional Consequences of Finasteride: Fool’s Gold American Journal of Men's Health · 2016
    10. Androgen Levels and Apoptosis in the Testis During Postnatal Development of Finasteride-Treated Male Rat Offspring Folia Histochemica Et Cytobiologica · 2015
    11. Organic Causes of Erectile Dysfunction in Men Under 40 Urologia Internationalis · 2013
    12. Finasteride-Associated Male Infertility Fertility and Sterility · 2010
    13. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998