Finasteride Delays Atherosclerosis Progression in Mice and Is Associated With a Reduction in Plasma Cholesterol in Men

January 2024 in “ Journal of lipid research ”

Patrick McQueen, Donald Molina, Ivan Pinos, Samuel A. Krug, Anna J. Taylor, Michael R. La Frano, Maureen A. Kane, Jaume Amengual

finasteride male-pattern baldness plasma cholesterol LDL-cholesterol monocytosis monocyte recruitment macrophage lesion content necrotic core area RNA sequencing inflammatory pathways bile acid metabolism oxidative phosphorylation cholesterol pathways Propecia

Studysummary In this study, finasteride was found to reduce cholesterol levels and delay atherosclerosis in LDL receptor-deficient mice, and men using finasteride reported lower cholesterol levels, suggesting potential cardiovascular benefits by improving lipid profiles.

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