Finasteride Delays Atherosclerosis Progression in Mice and Is Associated With a Reduction in Plasma Cholesterol in Men

    January 2024 in “ Journal of lipid research ”
    Patrick McQueen, Donald Molina, Ivan Pinos … Jaume Amengual
    Studysummary In this study, finasteride was found to reduce cholesterol levels and delay atherosclerosis in LDL receptor-deficient mice, and men using finasteride reported lower cholesterol levels, suggesting potential cardiovascular benefits by improving lipid profiles.
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    Research cited in this study 25

    1. The Interplay Between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation Biomedicines · 2022
    2. Finasteride Alleviates High Fat Associated Protein-Overload Nephropathy by Inhibiting Trimethylamine N-Oxide Synthesis and Regulating Gut Microbiota Frontiers in Physiology · 2022
    3. 5-Alpha Reductase Inhibitor Related Litigation: A Legal Database Review International Journal of Andrology · 2021
    4. The 5α-Reductase Inhibitor Finasteride Reduces Opioid Self-Administration in Animal Models of Opioid Use Disorder Journal of Clinical Investigation · 2021
    5. Ranitidine And Finasteride Inhibit The Synthesis And Release Of Trimethylamine N-Oxide And Mitigate Its Cardiovascular And Renal Damage Through Modulating Gut Microbiota International Journal of Biological Sciences · 2020
    6. Post-Finasteride Syndrome: A Surmountable Challenge for Clinicians Fertility and Sterility · 2020
    7. Long-Term Treatment with Finasteride Induces Apoptosis and Pathological Changes in Female Mice Human & Experimental Toxicology · 2019
    8. Anti-Androgenic Therapy with Finasteride Improves Cardiac Function, Attenuates Remodeling, and Reverts Pathologic Gene Expression After Myocardial Infarction in Mice Journal of Molecular and Cellular Cardiology · 2018
    9. Hormonal Treatment of Transgender Women with Oral Estradiol Transgender health · 2018
    10. Therapeutic Experience with Oral Finasteride for Androgenetic Alopecia in Female-to-Male Transgender Patients Clinical and Experimental Dermatology · 2017
    11. Scalp Hair Regrowth in Hormone-Treated Transgender Woman Transgender health · 2016
    12. Intermittent Low-Dose Finasteride Administration Is Effective for Treatment of Hirsutism in Adolescent Girls: A Pilot Study Journal of Pediatric and Adolescent Gynecology · 2014
    13. Preventive and Therapeutic Efficacy of Finasteride and Dutasteride in TRAMP Mice PLOS ONE · 2013
    14. Management of Transgenderism JAMA · 2013
    15. Changes of Metabolic Profile in Men Treated for Androgenetic Alopecia with 1 mg Finasteride Endocrine Regulations · 2010
    16. Inhibition of Human Steroid 5β-Reductase (AKR1D1) by Finasteride and Structure of the Enzyme-Inhibitor Complex Journal of Biological Chemistry · 2009
    17. Finasteride: Its Impact on Sexual Function and Prostate Cancer Journal of Cutaneous and Aesthetic Surgery · 2009
    18. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    19. Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men Mayo Clinic Proceedings · 2005
    20. Exogenous Testosterone Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum Testosterone The Journal of Clinical Endocrinology and Metabolism · 2005
    21. The Benefits of Finasteride for Hirsute Women with Polycystic Ovary Syndrome or Idiopathic Hirsutism Gynecological Endocrinology · 2003
    22. Finasteride, a 5alpha-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice PubMed · 1999
    23. Finasteride: The First 5α-Reductase Inhibitor Pharmacotherapy · 1993
    24. The Effect of Finasteride in Men with Benign Prostatic Hyperplasia The New England Journal of Medicine · 1992
    25. Effects of Finasteride (MK-906), a 5α-Reductase Inhibitor, on Circulating Androgens in Male Volunteers The Journal of Clinical Endocrinology and Metabolism · 1990

    Related research 8

    1. Similar Efficacy of Maintenance Treatment of Finasteride 1 mg Every Other Month Compared with Finasteride 1 mg Daily in Korean Men with Androgenetic Alopecia After Taking Finasteride 1 mg Daily for 1 Year Journal of The American Academy of Dermatology · 2020
    2. A Review on Finasteride: A 5-Alpha Reductase Inhibitor, Its Mechanism, Facts, and Benefits Journal of Drug Delivery and Therapeutics · 2019
    3. Clinical Observation on Acne Patients Taking Finasteride China Medical Abstract of Dermatology · 2013
    4. Finasteride in the Treatment of Japanese Men with Male Pattern Hair Loss PubMed · 2004
    5. Use of Finasteride in the Treatment of Men With Androgenetic Alopecia Journal of Investigative Dermatology Symposium Proceedings · 2003
    6. Advances in the Treatment of Male Androgenetic Alopecia: A Brief Review of Finasteride Studies PubMed · 2001
    7. Galenic-Pharmaceutical Study of Pieces of Proscar (Finasteride 5mg) and Finasteride 1mg Capsules Versus Propecia in the Treatment of Androgenetic Alopecia Hair transplant forum international · 2000
    8. Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases International Journal of Dermatology · 1995