Finasteride, a 5alpha-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice

    February 1999 in “ PubMed ”
    Tushar G. Kokate, Melissa Banks, Tamika Magee … Michael A. Rogawski
    Studysummary This study found that the anticonvulsant effects of progesterone against PTZ-induced seizures in mice require conversion to allopregnanolone, as shown by the reversal of these effects with a 5alpha-reductase inhibitor.
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    Research cited in this study 4

    1. Inhibition of Rat Alpha-Reductases by Finasteride: Evidence for Isozyme Differences in the Mechanism of Inhibition The Journal of Steroid Biochemistry and Molecular Biology · 1997
    2. The Enzyme and Inhibitors of 4-Ene-3-Oxosteroid 5α-Oxidoreductase Steroids · 1995
    3. Four-Amino Acid Segment in Steroid 5 Alpha-Reductase 1 Confers Sensitivity to Finasteride, a Competitive Inhibitor Journal of Biological Chemistry · 1992
    4. The Clinical Development of a 5α-Reductase Inhibitor, Finasteride The Journal of Steroid Biochemistry and Molecular Biology · 1990

    Related research 3

    1. Anticonvulsant Activity of Progesterone and Neurosteroids in Progesterone Receptor Knockout Mice Journal of Pharmacology and Experimental Therapeutics · 2004
    2. Stress-Induced Deoxycorticosterone-Derived Neurosteroids Modulate GABA A Receptor Function and Seizure Susceptibility Journal of Neuroscience · 2002
    3. Finasteride, a 5alpha-Reductase Inhibitor, Blocks the Anticonvulsant Activity of Progesterone in Mice PubMed · 1999