Finasteride Alleviates High Fat Associated Protein-Overload Nephropathy by Inhibiting Trimethylamine N-Oxide Synthesis and Regulating Gut Microbiota
August 2022
in “
Frontiers in Physiology
”
TLDR Finasteride may help treat kidney disease caused by a high-fat diet by reducing harmful toxins and improving gut bacteria.
The study investigated the effects of finasteride on high-fat diet (HFD)-induced chronic kidney disease (CKD) in 32 mice. Finasteride treatment reduced serum levels of the uremic toxin trimethylamine N-oxide (TMAO), improved kidney function, and altered gut microbiota composition by increasing beneficial bacteria like Akkermansia muciniphila. The findings suggest that finasteride could be a potential therapeutic agent for managing HFD-associated CKD by inhibiting TMAO synthesis and regulating gut microbiota.
