Finasteride Alleviates High Fat Associated Protein-Overload Nephropathy by Inhibiting Trimethylamine N-Oxide Synthesis and Regulating Gut Microbiota

    August 2022 in “ Frontiers in Physiology ”
    Zuoyuan Wang, Li You, Yuan Ren, Xiaoye Zhu, Xiao-Yi Mao, Xiaowan Liang, Tingting Wang, Yumeng Guo, Te Liu, Junmin Xue
    TLDR Finasteride may help treat kidney disease caused by a high-fat diet by reducing harmful toxins and improving gut bacteria.
    The study investigated the effects of finasteride on high-fat diet (HFD)-induced chronic kidney disease (CKD) in 32 mice. Finasteride treatment reduced serum levels of the uremic toxin trimethylamine N-oxide (TMAO), improved kidney function, and altered gut microbiota composition by increasing beneficial bacteria like Akkermansia muciniphila. The findings suggest that finasteride could be a potential therapeutic agent for managing HFD-associated CKD by inhibiting TMAO synthesis and regulating gut microbiota.
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