Ranitidine And Finasteride Inhibit The Synthesis And Release Of Trimethylamine N-Oxide And Mitigate Its Cardiovascular And Renal Damage Through Modulating Gut Microbiota

    January 2020 in “ International Journal of Biological Sciences ”
    Junfeng Liu, Lingyun Lai, Jun Lin … Te Liu
    Studysummary This study found that ranitidine and finasteride may have cardiovascular and renal protective effects in mice by inhibiting TMAO synthesis and improving gut microbiota composition.
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    Research cited in this study 2

    1. Treatment of Male Rats with Finasteride, an Inhibitor of 5alpha-Reductase Enzyme, Induces Long-Lasting Effects on Depressive-Like Behavior, Hippocampal Neurogenesis, Neuroinflammation, and Gut Microbiota Composition Psychoneuroendocrinology · 2018
    2. Analyzing the Innate Immunity of NIH Hairless Mice and the Impact of Gut Microbial Polymorphisms on Listeria Monocytogenes Infection Oncotarget · 2017

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    2. Ranitidine And Finasteride Inhibit The Synthesis And Release Of Trimethylamine N-Oxide And Mitigate Its Cardiovascular And Renal Damage Through Modulating Gut Microbiota International Journal of Biological Sciences · 2020