Ranitidine And Finasteride Inhibit The Synthesis And Release Of Trimethylamine N-Oxide And Mitigate Its Cardiovascular And Renal Damage Through Modulating Gut Microbiota

January 2020 in “ International Journal of Biological Sciences ”

Junfeng Liu, Lingyun Lai, Jun Lin, Jia-Jia Zheng, Xiao-li Nie, Xiaoye Zhu, Junmin Xue, Te Liu

Studysummary This study found that ranitidine and finasteride may have cardiovascular and renal protective effects in mice by inhibiting TMAO synthesis and improving gut microbiota composition.

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A study from 3 years ago found that ranitidine and finasteride can reduce the production and release of trimethylamine N-oxide (TMAO), which is linked to cardiovascular and renal damage, by altering gut microbiota in mice. The drugs may have therapeutic applications in preventing cardiovascular and chronic kidney diseases. The study suggests potential protective effects of the drugs on TMAO-related diseases. However, further research is needed to confirm their effectiveness on humans. No information related to hair loss, alopecia, or hair growth is provided.

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