The 5α-Reductase Inhibitor Finasteride Reduces Opioid Self-Administration in Animal Models of Opioid Use Disorder

    April 2021 in “ Journal of Clinical Investigation ”
    Gabriel D. Bossé, Roberto Cadeddu, Gabriele Floris … Randall T. Peterson
    Studysummary Finasteride reduces opioid use and withdrawal symptoms in animals.
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    Research cited in this study 21

    1. The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli Biomolecules · 2019
    2. The Efficacy and Use of Finasteride in Women: A Systematic Review International Journal of Dermatology · 2019
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    8. Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain Neuroendocrinology · 2015
    9. Adverse Effects of 5α-Reductase Inhibitors: What Do We Know, Don't Know, and Need to Know? Reviews in Endocrine and Metabolic Disorders · 2015
    10. Finasteride Attenuates Pathological Gambling in Patients With Parkinson's Disease Journal of Clinical Psychopharmacology · 2012
    11. A Preliminary Study of Finasteride in Tourette Syndrome Movement Disorders · 2011
    12. Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride Hormone Molecular Biology and Clinical Investigation · 2010
    13. An Overview on 5α-Reductase Inhibitors Steroids · 2009
    14. Finasteride Treatment and Neuroactive Steroid Formation PubMed · 2009
    15. Antipsychotic-Like Properties of 5-Alpha-Reductase Inhibitors Neuropsychopharmacology · 2008
    16. Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008
    17. Finasteride, a 5α-Reductase Inhibitor, Potentiates Antinociceptive Effects of Morphine, Prevents the Development of Morphine Tolerance and Attenuates Abstinence Behavior in the Rat Hormones and Behavior · 2007
    18. The Effects of Finasteride on Scalp Skin and Serum Androgen Levels in Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1999
    19. Effects of the 5α-Reductase Inhibitor Finasteride on Serum Levels of Gonadal, Adrenal, and Hypophyseal Hormones and Its Clinical Significance: A Prospective Clinical Study Steroids · 1998
    20. Clinical Pharmacokinetics and Pharmacodynamics of Finasteride Clinical Pharmacokinectics · 1996
    21. Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor Biochemistry · 1993

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    2. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992
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