research Molecular Phenotyping of Lichen Planopilaris Revealed Dysregulation of Cholesterol/Fatty Acid Metabolism, Fibrosis, and Mast Cell Pathways
Lichen planopilaris involves disrupted fat metabolism, increased scarring, and mast cell activity.
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research Central Centrifugal Cicatricial Alopecia Gene Expression Analysis Revealed Cholesterol, Fatty Acid, and Mast Cell Pathways
Targeting cholesterol, fatty acids, fibrosis, and mast cells may help treat CCCA.
research Frontal Fibrosing Alopecia Is Associated With Dysregulation of Cholesterol Biosynthesis Pathways, Fibrosis, and Mast Cells
Frontal Fibrosing Alopecia involves disrupted cholesterol pathways, fibrosis, and increased mast cells.
research Finasteride Delays Atherosclerosis Progression in Mice and Is Associated With a Reduction in Plasma Cholesterol in Men
Finasteride may lower cholesterol and slow heart disease progression.
research Finasteride Delays Atherosclerosis Progression and Reduces Hepatic Inflammation in Low-Density Lipoprotein Receptor-Deficient Mice
Finasteride may slow down heart disease by lowering cholesterol and reducing inflammation.
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5 / 85 resultscommunity Interesting article links major MPB theories to western diet (and life-style)
community Bile Acid-Mediated DHT Dysregulation Hypothesis
Elevated bile acids can inhibit the enzyme AKR1C2, leading to increased DHT levels, which may accelerate hair loss in those predisposed to androgenetic alopecia. Treatments mentioned include topical minoxidil and finasteride.
community 57% increased chance of pattern hair loss independently associated with the consumption of sugary beverages in men (p<0.001) Pt 2
Sugary beverages increase the risk of pattern hair loss in men by 57%. Treatments discussed include Minoxidil, finasteride, and RU58841.
community why hair restoration has not been progressed for last 20 years?
The conversation discusses the lack of significant advancements in hair loss treatments beyond finasteride and minoxidil, questioning if hair restoration technology has reached a dead end. Hair transplant technology has improved, but new medications face challenges with market entry, cost, accessibility, and long-term effectiveness.
community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders
Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.