The Postnatal Offspring of Finasteride-Treated Male Rats Shows Hyperglycemia, Elevated Hepatic Glycogen Storage, and Altered GLUT2, IR, and AR Expression in the Liver

January 2021 in “ International Journal of Molecular Sciences ”

Paulina Kur, Agnieszka Kolasa, Marta Grabowska, Andrzej Kram, Maciej Tarnowski, Irena Baranowska-Bosiacka, Sylwia Rzeszotek, Małgorzata Piasecka, Barbara Wiszniewska

finasteride hyperglycemia hepatic glycogen storage GLUT2 insulin resistance type 2 diabetes androgen receptor glucose metabolism Propecia high blood sugar liver glycogen storage glucose transporter type 2 AR

TLDR Finasteride-treated male rats' offspring had altered glucose metabolism, potentially increasing diabetes risk.

Male rats treated with finasteride had offspring that showed changes in glucose metabolism, including hyperglycemia, increased glycogen storage in the liver, and altered gene expression related to glucose metabolism in the liver. These effects suggest potential negative impacts on the metabolic health of the offspring, including an increased risk for insulin resistance and type 2 diabetes. The study highlights the importance of considering potential trans-generational effects of finasteride treatment.

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3 / 3 results

Antioxidant Enzyme Expression of mRNA and Protein in the Epididymis of Finasteride-Treated Male Rat Offspring During Postnatal Development

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The Postnatal Offspring of Finasteride-Treated Male Rats Shows Hyperglycemia, Elevated Hepatic Glycogen Storage, and Altered GLUT2, IR, and AR Expression in the Liver

Research cited in this study

research Antioxidant Enzyme Expression of mRNA and Protein in the Epididymis of Finasteride-Treated Male Rat Offspring During Postnatal Development

research Androgen Levels and Apoptosis in the Testis During Postnatal Development of Finasteride-Treated Male Rat Offspring

research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

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research Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men