Differential Gene Expression in Post-Finasteride Syndrome Patients

    July 2021 in “ The Journal of Sexual Medicine ”
    Skyler Howell, Weitao Song, Alexander W. Pastuszak, Mohit Khera
    Studysummary This study found significant differences in gene expression, particularly in androgen receptor activity, between men with post-finasteride syndrome and healthy controls, suggesting a potential biological basis for the syndrome.
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    Research cited in this study 16

    1. Penile Vascular Abnormalities in Young Men with Persistent Side Effects After Finasteride Use for the Treatment of Androgenic Alopecia Translational Andrology and Urology · 2020
    2. Post-Finasteride Syndrome: Risks and Side Effects of Finasteride for Androgenetic Alopecia Anais Brasileiros De Dermatologia · 2020
    3. Post-Finasteride Syndrome: An Induced Delusional Disorder with the Potential of a Mass Psychogenic Illness? Skin appendage disorders · 2019
    4. Research Brief: Self-Reports of Persistent Antiandrogenic, Estrogenic, Physical, and Psychological Effects of Finasteride Usage Among Men American Journal of Men's Health · 2018
    5. Sexual Dysfunction in Subjects Treated with Inhibitors of 5α-Reductase for Benign Prostatic Hyperplasia: A Comprehensive Review and Meta-Analysis International Journal of Andrology · 2017
    6. Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride PeerJ · 2017
    7. Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss The Journal of Clinical Endocrinology and Metabolism · 2016
    8. An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia International Journal of Andrology · 2016
    9. Immunohistochemical Evaluation of Androgen Receptor and Nerve Structure Density in Human Prepuce from Patients with Persistent Sexual Side Effects after Finasteride Use for Androgenetic Alopecia PLOS ONE · 2014
    10. Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride American Journal of Men's Health · 2014
    11. Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation The Journal of Steroid Biochemistry and Molecular Biology · 2014
    12. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    13. Finasteride 5mg and Sexual Side Effects: How Many Are Related to a Nocebo Phenomenon? The Journal of Sexual Medicine · 2007
    14. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
    15. Reversal of Caffeine-Induced Anxiety by Neurosteroid 3-Alpha-Hydroxy-5-Alpha-Pregnane-20-One in Rats Neuropharmacology · 2005
    16. Depression Related to Finasteride Administration for Androgenetic Alopecia Journal of Dermatology · 2002

    Related research 1

    1. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992