Differential Gene Expression in Post-Finasteride Syndrome Patients

    July 2021 in “ The Journal of Sexual Medicine ”
    Skyler Howell, Weitao Song, Alexander W. Pastuszak, Mohit Khera
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    Studysummary This study found significant differences in gene expression, particularly in androgen receptor activity, between men with post-finasteride syndrome and healthy controls, suggesting a potential biological basis for the syndrome.
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    The study investigated gene expression differences in men with post-finasteride syndrome (PFS) compared to healthy controls, focusing on genes affecting neurosteroid levels and androgen receptor activity. It included 26 men with PFS symptoms and 26 controls. Results showed significant differences in gene expression, with 1,446 genes over-expressed and 2,318 under-expressed in PFS patients. Androgen receptor expression was notably higher in PFS patients. However, no significant differences were found in serum levels of androgen receptor activity markers or trinucleotide repeats. The study provided evidence of gene expression correlating with PFS symptoms, suggesting a potential organic etiology, but acknowledged limitations such as selection bias and lack of pre-exposure data.
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