Penile Vascular Abnormalities in Young Men with Persistent Side Effects After Finasteride Use for the Treatment of Androgenic Alopecia

June 2020 in “ Translational Andrology and Urology ”

Mohit Khera, Jeffrey K. Than, James Anaissie, Ali Antar, Weitao Song, Boriss Losso, Alexander W. Pastuszak, Taylor P. Kohn, Jorge Rivera Mirabal

finasteride androgenic alopecia 5-alpha reductase inhibitors penile vascular abnormalities sexual side effects genitourinary side effects psycho-cognitive side effects anti-androgenic changes Propecia AGA 5ARI

TLDR Finasteride for hair loss may cause lasting sexual, genitourinary, mental, and anti-androgenic side effects in young men.

The study investigated the persistent side effects of finasteride use for androgenic alopecia in young men. The study found that the use of 5-alpha reductase inhibitors (5ARI) for AGA may lead to persistent sexual, genitourinary, psycho-cognitive, and anti-androgenic changes even after discontinuation of the therapy. The study also presented data on penile vascular abnormalities in young men with persistent side effects after finasteride use for the treatment of AGA. The study recommends additional clinical studies to assess non-sexual side effects that may persist after discontinuation of the drug and suggests that patients should be extensively counseled and monitored for possible side effects after initiation and discontinuation of this medication class.

View this study on tau.amegroups.com →

Discuss this study in the Community →

Research cited in this study

11 / 11 results

research A Review of the FAERS Data on 5-Alpha Reductase Inhibitors: Implications for Postfinasteride Syndrome

35 citations, June 2018 in “Urology”

The review suggests younger men taking 1 mg finasteride report more side effects, including sexual, skin, metabolic, and psychological issues.

research Post-Finasteride Syndrome and Post-SSRI Sexual Dysfunction: Two Sides of the Same Coin?

40 citations, April 2018 in “Endocrine”

PFS and PSSD are similar conditions with persistent sexual dysfunction after stopping medication.

Research Brief: Self-Reports of Persistent Antiandrogenic, Estrogenic, Physical, and Psychological Effects of Finasteride Usage Among Men

research Research Brief: Self-Reports of Persistent Antiandrogenic, Estrogenic, Physical, and Psychological Effects of Finasteride Usage Among Men

9 citations, January 2018 in “American Journal of Men's Health”

Finasteride use can cause lasting negative effects like sexual dysfunction, depression, anxiety, and cognitive issues.

Sexual Dysfunction in Subjects Treated with Inhibitors of 5α-Reductase for Benign Prostatic Hyperplasia: A Comprehensive Review and Meta-Analysis

research Sexual Dysfunction in Subjects Treated with Inhibitors of 5α-Reductase for Benign Prostatic Hyperplasia: A Comprehensive Review and Meta-Analysis

66 citations, April 2017 in “International Journal of Andrology”

Men taking 5α-reductase inhibitors for enlarged prostate have a higher chance of experiencing reduced sexual desire and erectile dysfunction.

research Persistent Erectile Dysfunction in Men Exposed to 5α-Reductase Inhibitors, Finasteride, or Dutasteride

50 citations, March 2017 in “PeerJ”

Using finasteride or dutasteride may cause long-lasting erectile dysfunction.

research Characteristics of Men Who Report Persistent Sexual Symptoms After Finasteride Use for Hair Loss

50 citations, September 2016 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride for hair loss may cause persistent sexual symptoms, depression, anxiety, and lower quality of life.

research Emotional Consequences of Finasteride: Fool’s Gold

31 citations, February 2016 in “American Journal of Men's Health”

Finasteride can cause serious emotional side effects; doctors should check patients' mental health history before prescribing.

An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia

research An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia

43 citations, January 2016 in “International Journal of Andrology”

Finasteride caused long-term sexual and non-sexual side effects in young men with hair loss.

research Persistent Sexual, Emotional, and Cognitive Impairment Post-Finasteride

81 citations, June 2014 in “American Journal of Men's Health”

Finasteride can cause lasting sexual, emotional, and cognitive issues, with varying severity.

research Persistent Sexual Side Effects of Finasteride: Could They Be Permanent?

112 citations, July 2012 in “The Journal of Sexual Medicine”

Finasteride may cause long-lasting sexual side effects.

Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

research Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

223 citations, December 2010 in “The Journal of Sexual Medicine”

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

Related Community Posts Join

6 / 1000+ results

community Is there a topical androgen receptor blocker so we don't have to fuck with the enzyme and destroy our allopregnanolone, but go and hit the end target straight?

in Treatment 47 upvotes 7 months ago

The conversation discusses topical androgen receptor blockers for hair loss, mentioning Clascoterone, Pyrilutamide, GT20029, and RU58841. Ketoconazole's effectiveness and application methods are also debated.

community FCE 28260: A Forgotten 5α-Reductase Inhibitor

in Research 330 upvotes 3 months ago

FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

in Progress Pictures 224 upvotes 8 months ago

A user shared their 11-year experience with spironolactone and nearly 5 years with finasteride for hair loss, recently adding oral minoxidil and stopping birth control. Various treatments were discussed, including organic options, checking for underlying health issues, considering dutasteride, and the potential role of progesterone in hair loss.

community Research about RU58841 /Why it was stopped

in Research/Science 29 upvotes 3 years ago

RU58841 showed promise for treating androgenic alopecia but research was halted due to financial and organizational changes. There were no significant safety concerns reported in human trials.

community 2024 guide for male pattern baldness: 10 take home messages from Dr. Moreno-Arrones

in Research/Science 243 upvotes 2 months ago

Effective treatments for male pattern baldness include finasteride, dutasteride, and oral minoxidil. Non-effective approaches include oils, shampoos, serums, laser therapies, massages, vitamins, and microneedling.

community Is this broscience? From More Plates, More Dates

in Research/Science 21 upvotes 9 months ago

The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

Related Research

4 / 4 results