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research Randomized clinical trial of astaxanthin supplement on serum inflammatory markers and ER stress‐apoptosis gene expression in PBMCs of women with PCOS

19 citations , July 2024 in “Journal of Cellular and Molecular Medicine”

In this study, women with PCOS who took 12 mg of Astaxanthin daily for 8 weeks showed a reduction in certain inflammatory markers and apoptosis-related genes, suggesting potential benefits for managing PCOS, though effects on symptoms like BMI and hirsutism were not significant.

Repurposing a Clinical Antimalarial for the Therapeutic Induction of Lethal ER Stress Targeting BRAF-Kinase Inhibitor-Resistant Malignant Melanoma

research 554 Repurposing a clinical antimalarial for the therapeutic induction of lethal ER stress targeting BRAF-kinase inhibitor-resistant malignant melanoma

April 2016 in “Journal of Investigative Dermatology”

This study identified mefloquine as a potent inducer of lethal ER stress that effectively eliminated vemurafenib-resistant and sensitive melanoma cells, suggesting its potential for repurposing as a melanoma treatment.

research Endoplasmic reticulum stress at the crossroads of progeria and atherosclerosis

11 citations , March 2019 in “EMBO molecular medicine”

This paper reviews the role of endoplasmic reticulum stress and the unfolded protein response in Hutchinson-Gilford progeria syndrome-related atherosclerosis, especially in vascular smooth muscle cells, but reports no clinical findings; intervention in these pathways is suggested as a potential therapeutic strategy.

Connection Between Granulosa Cell Pyroptosis and Oocyte Endoplasmic Reticulum Stress in a Mouse Model of Polycystic Ovary Syndrome

research Connection between granulosa cell pyroptosis and oocyte endoplasmic reticulum stress in a mouse model of polycystic ovary syndrome

2 citations , November 2025 in “Journal of Ovarian Research”

This study found that in a mouse model of PCOS, high androgen levels caused pyroptosis in ovarian granulosa cells and increased ER stress in oocytes, reducing oocyte maturation rates, while treatment with CPA and DMF improved these rates.

research Role of epigallocatechin-3-gallate from green tea in iron chelation and endoplasmic reticulum stress pathway in colorectal cancer cells

December 2018

This study found that in vitro, EGCG may help treat colorectal cancer by targeting iron chelation and the ER stress pathway, leading to apoptosis in cancer cells while sparing normal cells.

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Learn

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learn Scalp Micropigmentation

Is scalp micropigmentation a tattoo? Scalp micropigmentation is a specialized form of tattooing for hair loss.

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Community Join

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community Oral Minoxidil- Be Careful!!!!!

in Minoxidil 417 upvotes 1 year ago

Oral minoxidil can cause severe side effects, including heart issues, even at low doses. Users suggest starting with a lower dose or using topical treatments to minimize risks.

community Could fatty liver(other issues related to it..)play a role in Dupa/Aga?

6 upvotes 1 year ago

Fatty liver and related issues may influence hair loss conditions like Dupa/Aga. Treatments discussed include Minoxidil, finasteride, RU58841, myo-inositol, and L-glutamine.

community Serious Oral Minoxidil Side Effects

30 upvotes 5 years ago

A user experienced severe side effects, including heart-related symptoms, after increasing their oral minoxidil dosage to 5 mg, leading them to stop the medication and seek medical advice. Many users advised against high doses of oral minoxidil, suggesting anxiety as a possible cause, and recommended consulting a doctor or switching to topical treatments.

community DHT Isn't (Directly) Important

101 upvotes 1 year ago

Finasteride's potential side effects, especially sexual dysfunction, are discussed, with emphasis on hormonal balance between testosterone and estradiol. Users share experiences with finasteride, minoxidil, and dutasteride, highlighting the variability in side effects and the influence of mindset and lifestyle.

community 5 Months on topical Fin/Min progress: grows hair and boobs

in Progress Pictures 159 upvotes 11 months ago

The user experienced significant hair growth using topical finasteride and minoxidil but noticed nipple changes, suggesting early gynecomastia. They plan to stop the treatment and consider blood work to check hormonal balance.

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Experts

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Hair Transplant Surgeon
Dr. S. Iyer
Bangalore, Karnataka, India

Clinics

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Dr. S. Iyer