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GlossaryEndoplasmic Reticulum Stress (ER Stress)

cellular condition where protein folding machinery becomes overwhelmed

Endoplasmic Reticulum Stress (ER Stress) occurs when the endoplasmic reticulum, a cellular organelle responsible for protein folding and processing, becomes overwhelmed or dysfunctional. This can lead to the accumulation of misfolded or unfolded proteins, triggering a cellular response known as the Unfolded Protein Response (UPR) to restore normal function. If unresolved, ER stress can contribute to various diseases, including neurodegenerative disorders and diabetes.

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Repurposing a Clinical Antimalarial for the Therapeutic Induction of Lethal ER Stress Targeting BRAF-Kinase Inhibitor-Resistant Malignant Melanoma

research Repurposing a Clinical Antimalarial for the Therapeutic Induction of Lethal ER Stress Targeting BRAF-Kinase Inhibitor-Resistant Malignant Melanoma

April 2016 in “Journal of Investigative Dermatology”

Mefloquine, an antimalarial drug, is effective in killing melanoma cells resistant to other treatments by causing lethal stress in the cells.

research Endoplasmic Reticulum Stress at the Crossroads of Progeria and Atherosclerosis

11 citations , March 2019 in “EMBO molecular medicine”

A defective protein in progeria causes cell death and atherosclerosis, but a treatment targeting cell stress may reduce these effects.

research Role of Epigallocatechin-3-Gallate from Green Tea in Iron Chelation and Endoplasmic Reticulum Stress Pathway in Colorectal Cancer Cells

December 2018

Green tea compound EGCG could potentially treat colorectal cancer by removing iron and causing stress in cancer cells leading to their death.

research Endoplasmic Reticulum Stress Upregulates NKG2D Ligands in the Hair Follicle

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Stress in hair follicle cells increases certain immune-related proteins, which might contribute to hair loss conditions.

research The Interplay Between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation

October 2022 in “Biomedicines”

Finasteride in male rats causes liver and metabolic issues in their offspring.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Oral Minoxidil- Be Careful!!!!!

in Minoxidil 417 upvotes 4 months ago

Oral minoxidil can cause severe side effects, including heart issues, even at low doses. Users suggest starting with a lower dose or using topical treatments to minimize risks.

community Could fatty liver(other issues related to it..)play a role in Dupa/Aga?

in Treatment 7 upvotes 11 months ago

Fatty liver and related issues may influence hair loss conditions like Dupa/Aga. Treatments discussed include Minoxidil, finasteride, RU58841, myo-inositol, and L-glutamine.

community Why the fu*k do people behave like this?

in Chat 385 upvotes 2 years ago

People making comments on others' hair loss, and the different strategies used to deal with it. Treatments mentioned include finasteride and minoxidil.

community Serious Oral Minoxidil Side Effects

in Minoxidil 30 upvotes 4 years ago

A user experienced severe side effects, including heart-related symptoms, after increasing their oral minoxidil dosage to 5 mg, leading them to stop the medication and seek medical advice. Many users advised against high doses of oral minoxidil, suggesting anxiety as a possible cause, and recommended consulting a doctor or switching to topical treatments.

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