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GlossaryEndoplasmic Reticulum Stress (ER Stress)

cellular condition where protein folding machinery becomes overwhelmed

Endoplasmic Reticulum Stress (ER Stress) occurs when the endoplasmic reticulum, a cellular organelle responsible for protein folding and processing, becomes overwhelmed or dysfunctional. This can lead to the accumulation of misfolded or unfolded proteins, triggering a cellular response known as the Unfolded Protein Response (UPR) to restore normal function. If unresolved, ER stress can contribute to various diseases, including neurodegenerative disorders and diabetes.

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Repurposing a Clinical Antimalarial for the Therapeutic Induction of Lethal ER Stress Targeting BRAF-Kinase Inhibitor-Resistant Malignant Melanoma

research Repurposing a Clinical Antimalarial for the Therapeutic Induction of Lethal ER Stress Targeting BRAF-Kinase Inhibitor-Resistant Malignant Melanoma

April 2016 in “Journal of Investigative Dermatology”

Mefloquine, an antimalarial drug, is effective in killing melanoma cells resistant to other treatments by causing lethal stress in the cells.

research Endoplasmic Reticulum Stress at the Crossroads of Progeria and Atherosclerosis

11 citations, March 2019 in “EMBO molecular medicine”

A defective protein in progeria causes cell death and atherosclerosis, but a treatment targeting cell stress may reduce these effects.

research Role of Epigallocatechin-3-Gallate from Green Tea in Iron Chelation and Endoplasmic Reticulum Stress Pathway in Colorectal Cancer Cells

December 2018

Green tea compound EGCG could potentially treat colorectal cancer by removing iron and causing stress in cancer cells leading to their death.

research Endoplasmic Reticulum Stress Upregulates NKG2D Ligands in the Hair Follicle

April 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Stress in hair follicle cells increases certain immune-related proteins, which might contribute to hair loss conditions.

research The Interplay Between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation

October 2022 in “Biomedicines”

Finasteride in male rats causes liver and metabolic issues in their offspring.

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community Why the fu*k do people behave like this?

in Chat 385 upvotes 1 year ago

People making comments on others' hair loss, and the different strategies used to deal with it. Treatments mentioned include finasteride and minoxidil.

community DHT/Testosterone levels in scalp Fin VS Dut.

in Finasteride/Dutasteride 60 upvotes 4 months ago

Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

community Shiseido/Replicel RCH-01 trial results were finally shared online

in Treatment 42 upvotes 4 years ago

The Shiseido/Replicel RCH-01 trial results were disappointing and ineffective. Users expressed skepticism and frustration, suggesting alternatives like Tsuji or simply accepting baldness.

community I am putting my hair loss treatment on hold until my mental health is better.

in Update 21 upvotes 2 months ago

OP is pausing hair loss treatments to focus on mental health due to anxiety and side effects from RU58841. They plan to try topical finasteride and minoxidil after recovering from pneumonia.

community Just to show you the superiority of dutasteride over finasteride (it's huge)

in Research/Science 58 upvotes 5 months ago

Dutasteride is shown to be significantly more effective than finasteride for treating male androgenic alopecia. Users discuss the difficulty of obtaining dutasteride in some countries and share personal experiences with its effectiveness and side effects.

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