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GlossaryEndoplasmic Reticulum Stress (ER Stress)

cellular condition where protein folding machinery becomes overwhelmed

Endoplasmic Reticulum Stress (ER Stress) occurs when the endoplasmic reticulum, a cellular organelle responsible for protein folding and processing, becomes overwhelmed or dysfunctional. This can lead to the accumulation of misfolded or unfolded proteins, triggering a cellular response known as the Unfolded Protein Response (UPR) to restore normal function. If unresolved, ER stress can contribute to various diseases, including neurodegenerative disorders and diabetes.

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research The Interplay Between Finasteride-Induced Androgen Imbalance, Endoplasmic Reticulum Stress, Oxidative Stress, and Liver Disorders in Paternal and Filial Generation

October 2022 in “Biomedicines”

Finasteride in male rats causes liver and metabolic issues in their offspring.

research Role of Epigallocatechin-3-Gallate from Green Tea in Iron Chelation and Endoplasmic Reticulum Stress Pathway in Colorectal Cancer Cells

December 2018

Green tea compound EGCG could potentially treat colorectal cancer by removing iron and causing stress in cancer cells leading to their death.

Repurposing a Clinical Antimalarial for the Therapeutic Induction of Lethal ER Stress Targeting BRAF-Kinase Inhibitor-Resistant Malignant Melanoma

research Repurposing a Clinical Antimalarial for the Therapeutic Induction of Lethal ER Stress Targeting BRAF-Kinase Inhibitor-Resistant Malignant Melanoma

April 2016 in “Journal of Investigative Dermatology”

Mefloquine, an antimalarial drug, is effective in killing melanoma cells resistant to other treatments by causing lethal stress in the cells.

research Endoplasmic Reticulum Stress at the Crossroads of Progeria and Atherosclerosis

11 citations , March 2019 in “EMBO molecular medicine”

A defective protein in progeria causes cell death and atherosclerosis, but a treatment targeting cell stress may reduce these effects.

research Development of New Treatment Modality for Male Infertility Using Phytopharmaceuticals

September 2018 in “Translational andrology and urology”

MOTILIPERM may help treat male infertility by reducing stress in cells.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

MagicBold in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community Why is Kevin Mann (Haircafe) Hated?

in Chat 62 upvotes 2 years ago

Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

community Finasteride vs Dutasteride: The Science

in Research/Science 166 upvotes 2 years ago

The conversation compares Finasteride and Dutasteride for hair loss treatment, discussing their effectiveness and side effects. Users share personal results and consider combining treatments like Dutasteride with RU58841.

community DHT/Testosterone levels in scalp Fin VS Dut.

in Finasteride/Dutasteride 66 upvotes 1 year ago

Dutasteride raises scalp testosterone by 99%, which may not be ideal for those sensitive to all androgens. Some argue finasteride's balancing act might be better, while others believe dutasteride is superior for hair regrowth.

community Oral Minoxidil- Be Careful!!!!!

in Minoxidil 417 upvotes 8 months ago

Oral minoxidil can cause severe side effects, including heart issues, even at low doses. Users suggest starting with a lower dose or using topical treatments to minimize risks.

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