Dysregulation of Leukemia Inhibitory Factor (LIF) Signaling Pathway by Supraphysiological Dose of Testosterone in Female Sprague Dawley Rats During Development of Endometrial Receptivity

January 2025 in “ Biomedicines ”

Allia Najmie Muhammad Yusuf, Mohd Fariz Amri, Azizah Ugusman, Adila A. Hamid, Izzat Zulhilmi Abd Rahman, Mohd Helmy Mokhtar

testosterone Leukaemia Inhibitory Factor LIF LIFR JAK1 STAT3 MUC1 finasteride anastrozole Propecia Arimidex

TLDR High testosterone levels can harm fertility by disrupting the LIF signaling pathway in the uterus.

The study on 30 female Sprague Dawley rats examined the effects of a supraphysiological dose of testosterone on the LIF signaling pathway and endometrial receptivity. Testosterone treatment significantly reduced endometrial and myometrial thickness, decreased the number of glands, and downregulated mRNA levels of LIF, LIFR, JAK1, and STAT3, while upregulating MUC1. These changes suggest that high testosterone levels impair endometrial receptivity by disrupting the LIF signaling pathway, potentially affecting fertility. The combination of testosterone with inhibitors like finasteride and anastrozole did not fully counteract these effects, highlighting the need for further research on androgenic impacts on fertility.

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Research cited in this study

4 / 4 results

Supraphysiological Dose of Testosterone Impairs the Expression and Distribution of Sex Steroid Receptors During Endometrial Receptivity Development in Female Sprague-Dawley Rats

research Supraphysiological Dose of Testosterone Impairs the Expression and Distribution of Sex Steroid Receptors During Endometrial Receptivity Development in Female Sprague-Dawley Rats

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High doses of testosterone disrupt hormone levels and receptor expression in the uterus, affecting fertility.

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Dysregulation of Leukemia Inhibitory Factor (LIF) Signaling Pathway by Supraphysiological Dose of Testosterone in Female Sprague Dawley Rats During Development of Endometrial Receptivity

Research cited in this study

research Supraphysiological Dose of Testosterone Impairs the Expression and Distribution of Sex Steroid Receptors During Endometrial Receptivity Development in Female Sprague-Dawley Rats

research Effects of Testosterone on the Expression of Connexin 26 and Connexin 43 in the Uterus of Rats During Early Pregnancy

research Testosterone Reduces Tight Junction Complexity and Down-Regulates Expression of Claudin-4 and Occludin in the Endometrium in Ovariectomized, Sex-Steroid Replacement Rats

research Testosterone Down-Regulates Expression of αVβ3-Integrin, E-Cadherin, and Mucin-1 During Uterine Receptivity Period in Rats

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