Ultrasound-Activated GelMA Hydrogel Loaded with MSC-EVs Promotes Functional Regeneration of Skin Vasculature, Nerves, and Appendages

    Bingyang Yu, Chao Zhang, Dongzhen Zhu … Sha Huang
    Studysummary This study found that combining ultrasound with a GelMA hydrogel able to deliver mesenchymal stem cell-derived vesicles significantly improved wound healing in a mouse model by enhancing fibroblast activity, promoting re-epithelialization, and facilitating hair follicle regeneration, highlighting a novel approach to skin regeneration therapy.
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    Research cited in this study 3

    1. Fibroblasts and Endothelial Cells Interplay Drives Hypertrophic Scar Formation: Insights from In Vitro and In Vivo Models Bioengineering & Translational Medicine · 2023
    2. Integrating Zinc/Silicon Dual Ions With 3D-Printed GelMA Hydrogel Promotes In Situ Hair Follicle Regeneration International Journal of bioprinting · 2023
    3. Wound Healing and Skin Regeneration Cold Spring Harbor Perspectives in Medicine · 2015