Hydrogel-Mediated Extracellular Vesicles for Enhanced Wound Healing: The Latest Progress and Their Prospects for 3D Bioprinting

February 2024 in “ Journal of nanobiotechnology ”

Yi Zheng, Chuqiao Pan, Peng Xu, Kai Li

extracellular vesicles hydrogel tissue regeneration inflammation vascularization silk fibroin alginate hyaluronic acid 3D bioprinting wound healing biomaterials tissue scaffolds EVs hydrogels 3D printing wound dressings

Studysummary This review explores how combining extracellular vesicles with hydrogels and utilizing 3D bioprinting technologies creates innovative composite systems for wound healing, offering advanced mechanical and biological support, while addressing challenges like degradation and regulatory issues in clinical applications. Our plain-language summary of this paper — not a Tressless recommendation.

The document reviews the latest advancements in hydrogel-mediated extracellular vesicles (EVs) for enhanced wound healing and their potential in 3D bioprinting. It highlights the therapeutic benefits of EVs in promoting tissue regeneration, reducing inflammation, and enhancing vascularization. The integration of hydrogels with EVs improves stability and delivery, leading to better healing outcomes. Various biomaterials like silk fibroin, alginate, and hyaluronic acid are discussed for their effectiveness in creating EV-loaded hydrogels. The review also explores the potential of 3D bioprinting to create customized wound dressings and tissue scaffolds, suggesting a promising future for personalized and precise wound care solutions. Challenges such as scalability, regulatory considerations, and clinical translation are also addressed.

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