Fibroblasts and Endothelial Cells Interplay Drives Hypertrophic Scar Formation: Insights from In Vitro and In Vivo Models

    Yaxin Tan, Mengde Zhang, Yi Kong, Fanliang Zhang, Yuzhen Wang, Yuyan Huang, Wei Song, Li Zhao, Linhao Hou, Liting Liang, Xu Guo, Qinghua Liu, Feng Yu, Chao Zhang, Xiaobing Fu, Sha Huang
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    Studysummary This study found that crosstalk between fibroblasts and endothelial cells significantly contributes to hypertrophic scar formation by enhancing fibroblast activity through cytokine secretion, with pathway analyses suggesting molecular targets for potential therapeutic interventions.
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