Regenerating Hair in Prevascularized Tissue Space Formed by a Controllable Foreign Body Reaction

The study explored a novel method for hair regeneration by using a prevascularized collagen fiber (PVCF) space created through a controlled foreign body reaction, as opposed to traditional intracutaneous transplantation. This PVCF space offered a larger tissue volume, lower Young's modulus, higher flexibility, and a more permeable surface with a rich vascular network. These characteristics led to reduced cell apoptosis and necrosis, resulting in the generation of approximately 289 mature hairs per site, compared to 177 hairs per site with intracutaneous transplantation. The findings suggested that this approach could enhance the microenvironment for grafts both physiologically and mechanically, offering a cost-effective and simple fabrication process.