Regenerating Hair in Prevascularized Tissue Space Formed by a Controllable Foreign Body Reaction

The study explored a novel method for hair regeneration by using a prevascularized collagen fiber (PVCF) space created through a controlled foreign body reaction. This subcutaneous space was found to be more advantageous than traditional intracutaneous transplantation due to its larger tissue volume, lower Young's modulus, higher flexibility, and better vascular network. The PVCF environment resulted in less cell apoptosis and necrosis, and a higher number of mature hairs (approximately 289 per site) compared to intracutaneous transplantation (approximately 177 per site). The findings suggested that this approach could improve the microenvironment for graft sites both physiologically and mechanically, offering a promising, low-cost, and simple fabrication process for hair regeneration.