Regenerating Hair in Prevascularized Tissue Space Formed by a Controllable Foreign Body Reaction

    November 2020 in “ Advanced Functional Materials ”
    Lunan Yang, Yong Miao, Yuqing Liu, Shiyi Chen, Yuxin Chen, Wei‐Wen Liu, Jin Wang, Wen Zhong, Quan Wang, Zhiqi Hu, Malcolm Xing
    Studysummary This study found that a prevascularized collagen fiber space improved hair generation compared to intracutaneous transplantation by providing a better microenvironment for transplanted cells.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The study explored a novel method for hair regeneration by using a prevascularized collagen fiber (PVCF) space created through a controlled foreign body reaction. This subcutaneous space was found to be more advantageous than traditional intracutaneous transplantation due to its larger tissue volume, lower Young's modulus, higher flexibility, and better vascular network. The PVCF environment resulted in less cell apoptosis and necrosis, and a higher number of mature hairs (approximately 289 per site) compared to intracutaneous transplantation (approximately 177 per site). The findings suggested that this approach could improve the microenvironment for graft sites both physiologically and mechanically, offering a promising, low-cost, and simple fabrication process for hair regeneration.
    Discuss this study in the Community →

    Research cited in this study

    18 / 18 results