Photobiomodulation: The Clinical Applications of Low-Level Light Therapy

January 2021 in “ Aesthetic Surgery Journal ”

Graeme E. Glass

Low-Level Light Therapy photobiomodulation androgenic alopecia red light near-infrared light dermal fibroblast hair density hair thickness LLLT red light therapy near-infrared light therapy

Studysummary This review suggested that low-level light therapy using red/near-infrared light could be a safe and effective treatment for various skin and hair conditions, though more robust trials are needed to solidify its clinical utility.

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Research cited in this study

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Comparative Effectiveness of Low-Level Laser Therapy for Adult Androgenic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

research Comparative Effectiveness of Low-Level Laser Therapy for Adult Androgenic Alopecia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

21 citations , January 2019 in “Lasers in Medical Science”

This review found that low-level laser therapy significantly increased hair density in adults with androgenic alopecia compared to sham treatments, with greater effects observed at lower treatment frequencies.

research Shedding Light on the FDA’s 510(k) Approvals Process: Low-Level Laser Therapy Devices Used in the Treatment of Androgenetic Alopecia

6 citations , September 2018 in “Journal of Dermatological Treatment”

This review examines the FDA's 510(k) approval process for low-level laser therapy devices used in treating androgenetic alopecia and reports no new clinical findings.

Efficacy and Safety of Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Self-Comparison, Sham Device-Controlled Trial

research Efficacy and Safety of Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Self-Comparison, Sham Device-Controlled Trial

31 citations , June 2018 in “Dermatologic Surgery”

In this randomized, double-blind trial, researchers observed that low-level laser therapy led to significantly greater hair regrowth on treated areas compared to a sham treatment in patients with androgenetic alopecia over 24 weeks, suggesting it as a potentially effective and safe option.

Comparison of the Effects of 665 nm Low-Level Diode Laser Hat Versus a Combination of 665 nm and 808 nm Low-Level Diode Laser Scanner on Hair Growth in Androgenic Alopecia

research Comparison of the Effects of 665 nm Low-Level Diode Laser Hat Versus a Combination of 665 nm and 808 nm Low-Level Diode Laser Scanner on Hair Growth in Androgenic Alopecia

24 citations , May 2017 in “Journal of Cosmetic and Laser Therapy”

This study reported that a new laser scanner using 655 nm red and 808 nm infrared lasers significantly improved hair density in patients with androgenic alopecia compared to both a laser hat and no treatment, without observable adverse effects.

research Novel Approach to Treating Androgenetic Alopecia in Females With Photobiomodulation (Low-Level Laser Therapy)

33 citations , March 2017 in “Dermatologic Surgery”

In this clinical study, low-level laser therapy using the HANDI-DOME LASER device increased hair counts by 51% compared to controls, indicating its potential as a safe and effective treatment for androgenetic alopecia in women aged 18 to 60.

research Low-Level Laser Therapy and Hair Regrowth: An Evidence-Based Review

60 citations , December 2015 in “Lasers in Medical Science”

This review concluded that FDA-cleared low-level laser therapy devices are safe and effective for patients with male and female pattern hair loss who do not respond to or tolerate standard treatments.

research The Growth of Human Scalp Hair in Females Using Visible Red Light Laser and LED Sources

81 citations , August 2014 in “Lasers in Surgery and Medicine”

This study found that low-level laser therapy significantly increased hair growth in women with androgenic alopecia, achieving a 37% greater increase in hair counts compared to placebo.

Efficacy and Safety of a Low-Level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-Controlled, Double-Blind Study

research Efficacy and Safety of a Low-Level Laser Device in the Treatment of Male and Female Pattern Hair Loss: A Multicenter, Randomized, Sham Device-Controlled, Double-Blind Study

147 citations , January 2014 in “American Journal of Clinical Dermatology”

This study found that low-level laser treatment with the HairMax Lasercomb significantly increased terminal hair density in both men and women with pattern hair loss, with no serious adverse events reported.

research Cause of Androgenic Alopecia

17 citations , October 2013 in “Plastic and reconstructive surgery. Global open”

This review examines misconceptions and gaps in the understanding of androgenic alopecia (AGA) etiopathogenesis, offering new perspectives but no new experimental results.

research The Growth of Human Scalp Hair Mediated by Visible Red Light Laser and LED Sources in Males

117 citations , September 2013 in “Lasers in Surgery and Medicine”

This study found that low level laser therapy at 655 nm significantly increased hair counts in males with androgenetic alopecia.

research Low-Level Laser Therapy for Treatment of Hair Loss

165 citations , August 2013 in “Lasers in Surgery and Medicine”

This review discusses the potential mechanisms and evidence supporting low-level laser therapy for stimulating hair growth in men and women, while noting its safety and effectiveness but needing further study on specific parameters.

research Low-Level Light Therapy for Androgenetic Alopecia: A 24-Week, Randomized, Double-Blind, Sham Device-Controlled Multicenter Trial

106 citations , April 2013 in “Dermatologic Surgery”

This study found that low-level light therapy significantly increased hair density and diameter in androgenetic alopecia patients compared to a sham device, suggesting it could be an effective treatment option.

research HairMax LaserComb Laser Phototherapy Device in the Treatment of Male Androgenetic Alopecia

160 citations , January 2009 in “Clinical Drug Investigation”

This study found that the HairMax LaserComb® significantly increased hair density and was safe and well tolerated for treating androgenetic alopecia in men compared to a sham device.