1235 citations
,
December 2013 in “Nature” This study found that skin fibroblasts in mice arise from two distinct lineages which contribute differently to dermal structure and repair, impacting hair follicle formation during wound healing.
207 citations
,
March 2012 in “Development” In this mouse study, researchers found that dermal Wnt signaling/β-catenin activity is essential for fibroblast proliferation and initiating hair follicle formation by interacting with epidermal Wnt ligands.
128 citations
,
August 2020 in “Cell stem cell” In this study, researchers found that extrafollicular progenitors marked by Hic1 are the main contributors to reparative fibroblasts in wound repair, with potential to modulate healing outcomes through genetic and pharmacological interventions.
123 citations
,
January 2020 in “International Journal of Molecular Sciences” This review discusses the role of fibroblast heterogeneity in determining skin scarring versus regeneration and reports no new results, highlighting opportunities for developing antiscarring therapies.
115 citations
,
December 2017 in “Wiley Interdisciplinary Reviews-Developmental Biology” This review discusses the origins, differentiation, and function of dermal fibroblasts in skin development and healing, reporting no new clinical results.