Oxidative Stress in Hair Follicle Development and Hair Growth: Signaling Pathways, Intervening Mechanisms and Potential of Natural Antioxidants

June 2024 in “ Journal of Cellular and Molecular Medicine ”

Fanpan Du, Jingjie Li, Shiqian Zhang, Xuemei Zeng, Jing Nie, Zheng Li

oxidative stress hair follicle hair loss signalling pathways antioxidant pathway natural antioxidants

TLDR Natural antioxidants may help prevent hair loss by reducing oxidative stress.

Oxidative stress (OS) significantly impacts hair follicle development and hair growth by disrupting the balance between free radicals and antioxidants, leading to hair loss. It affects several signaling pathways crucial for cellular activities, such as Keap1/Nrf2/ARE and Wnt/β-catenin. Excessive OS can cause DNA damage and apoptosis in hair follicles, potentially leading to alopecia. Natural antioxidants, including compounds like resveratrol, arctiin, morroniside, and taxifolin, show promise in mitigating OS effects, promoting hair growth, and reducing hair loss by enhancing antioxidant enzyme activity and inhibiting factors like 5α-reductase and DHT. While animal and cellular studies demonstrate these effects, further clinical research is needed to understand the molecular mechanisms and evaluate the clinical application of these bioactive components for treating hair loss.

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