Effects of Taxifolin From Enzymatic Hydrolysis of Rhododendron Mucronulatum on Hair Growth Promotion

September 2022 in “ Frontiers in Bioengineering and Biotechnology ”

Sunmin Park, Yi-Chang He, Chun Gong, Wei Gao, Young-Soo Bae, Chuanling Si, Kwang‐Hyun Park, Sun-Eun Choi

taxifolin Rhododendron mucronulatum anti-inflammatory antioxidant apoptosis dermal papilla cells Dihydrotestosterone DHT IGF-1 TGF-β1 cell death hair follicle cells Insulin-like Growth Factor 1 Transforming Growth Factor Beta 1

TLDR Taxifolin from Rhododendron mucronulatum may help prevent hair loss and promote hair growth.

The study investigated the effects of taxifolin, extracted from Rhododendron mucronulatum, on hair growth and hair loss prevention. The research found that taxifolin has strong anti-inflammatory and antioxidant activities, which can regulate the apoptosis of dermal papilla cells, closely related to hair loss. It also showed a dose-dependent inhibitory effect on Dihydrotestosterone (DHT) production, a hormone associated with hair loss, and increased the expression of IGF-1, a key factor in hair growth. Furthermore, taxifolin reduced the expression of TGF-β1, an inhibitor of hair growth. These results suggest that taxifolin could potentially be used in the development of hair loss treatments with no side effects.

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