SIRT1 Downregulation Provokes Immune-Inflammatory Responses in Hair Follicle Outer Root Sheath Cells and May Contribute to Development of Alopecia Areata

    May 2023 in “ Journal of Dermatological Science ”
    Lihua Hao, Kyung‐Hwa Nam, Geon‐Jong Lee … Jin Park
    Studysummary This research found that reduced expression of SIRT1 in human scalp tissue may contribute to alopecia areata development by inducing immune-inflammatory responses in hair follicle cells, suggesting that SIRT1 plays a regulatory role in hair follicle immunity.
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    Research cited in this study 13

    1. Two Phase 3 Trials of Baricitinib for Alopecia Areata The New England Journal of Medicine · 2022
    2. The Role of Serum Th1, Th2, and Th17 Cytokines in Patients with Alopecia Areata: Clinical Implications Cells · 2021
    3. Ritlecitinib And Brepocitinib Demonstrate Significant Improvement In Scalp Alopecia Areata Biomarkers ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2021
    4. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    5. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    6. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    7. Alopecia Areata: Treatment Options and Efficacy Journal of the American Academy of Dermatology · 2017
    8. Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles Scientific reports · 2017
    9. CXCR3 Blockade Inhibits T Cell Migration Into the Skin and Prevents Development of Alopecia Areata Journal of Immunology · 2016
    10. The Role of Lymphocytes in the Development and Treatment of Alopecia Areata Expert Review of Clinical Immunology · 2015
    11. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    12. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    13. Alopecia Areata Update Journal of The American Academy of Dermatology · 2010

    Related research 3

    1. Expression of E6 and E7 Papillomavirus Oncogenes in the Outer Root Sheath of Hair Follicles Extends the Growth Phase and Bypasses Resting at Telogen PubMed · 2000
    2. Effects of Epidermal Growth Factor on the Morphology and Patterns of DNA Synthesis in Isolated Human Hair Follicles ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1994
    3. Outer Root Sheath Keratinization in Anagen and Catagen of the Mammalian Hair Follicle: A Seventh Distinct Type of Keratinization in the Hair Follicle - Trichilemmal Keratinization PubMed · 1981