TLDR SIRT3 and SIRT7 decrease, while NFATC1 and PDL-1 increase in Androgenetic Alopecia.
This study investigated the expression patterns of the genes SIRT3, SIRT7, NFATC1, and PDL-1 in Androgenetic Alopecia (AGA) by analyzing mesenchymal stem cells from six men with AGA. The results showed that SIRT3 and SIRT7, which typically decrease during hair follicle aging, were also reduced in AGA samples. Conversely, NFATC1 and PDL-1, which usually increase during hair follicle aging, were elevated in AGA samples. Bioinformatic analyses supported these findings, suggesting that while SIRT3 and SIRT7 are crucial in AGA development, further research is needed to understand the roles of NFATC1 and PDL-1 and their potential as therapeutic targets.
Androgenetic alopecia, or hair loss, is caused by a mix of genetics, hormones, and environment, where testosterone affects hair growth and causes hair to become smaller and grow for a shorter time.
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