Expression of Signal Transducer and Activator of Transcription-3 in Androgenetic Alopecia: A Case Control Study

January 2022 in “ Skin Pharmacology and Physiology ”

Akmal S Hassan, Mohammad Qassim Al-Dhoun, Olfat G. Shaker, Aya M AlOrbani

Signal Transducer and Activator of Transcription-3 STAT3 androgenetic alopecia JAK-STAT pathway androgenic alopecia

TLDR Higher STAT3 levels are found in hair loss areas, but not linked to hair loss severity.

This study investigated the expression of Signal Transducer and Activator of Transcription-3 (STAT3) in patients with androgenetic alopecia. The research included 25 patients and found that scalp tissue affected by androgenetic alopecia exhibited significantly higher levels of STAT3 gene expression compared to unaffected areas (p < 0.001). However, there was no significant correlation between STAT3 expression levels and the severity of hair loss (p = 0.660). The study suggests an upregulation of STAT3 in androgenetic alopecia and highlights the need for further research to explore the role of the JAK-STAT pathway in the condition's pathogenesis. The study's limitations include its small sample size.

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Research cited in this study

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research The Relationship of Androgenetic Alopecia Severity with Epicardial Fat Thickness

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Expression of Signal Transducer and Activator of Transcription-3 in Androgenetic Alopecia: A Case Control Study

Research cited in this study

research The Relationship of Androgenetic Alopecia Severity with Epicardial Fat Thickness

research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

research Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration

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