Hyaluronidase Modulates Inflammatory Response and Accelerates Cutaneous Wound Healing

    November 2014 in “ PLoS ONE ”
    Márcio Fronza, Guilherme Ferreira Caetano, Marcel Nani Leite, Claudia S. Bitencourt, Francisco Wanderley Garcia Paula‐Silva, Thiago Antônio Moretti de Andrade, Marco Andrey Cipriani Frade, Irmgard Merfort, Lúcia Helena Faccioli
    TLDR Hyaluronidase speeds up wound healing and reduces inflammation.
    The study investigated the effects of bovine testes hyaluronidase (HYAL) on cutaneous wound healing using in vitro and in vivo models. HYAL was found to enhance fibroblast migration and proliferation in vitro and significantly improve wound healing in vivo in Wistar rats. Specifically, HYAL-treated wounds showed faster reepithelialization, with wound closure areas reaching 38% and 46% for 16 U and 32 U HYAL treatments, compared to 19% in controls. Histological and biochemical analyses indicated that HYAL-treated wounds had increased granulation tissue, reduced edema, and a modulated inflammatory response. Additionally, HYAL increased the expression of PPAR γ and PPAR β/δ, collagen content, and angiogenesis in the early stages of healing. These findings suggested that HYAL could accelerate wound healing and be beneficial for treating wound disorders.
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