Yellow Facial Papules Associated With Frontal Fibrosing Alopecia: A Distinct Histologic Pattern and Response to Isotretinoin

    September 2017 in “ Journal of the American Academy of Dermatology ”
    Ana Pedrosa, Ana Filipa Duarte, Eckart Haneke, Osvaldo Correia
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    TLDR Oral isotretinoin effectively treats yellow facial papules in frontal fibrosing alopecia patients.
    The document discussed frontal fibrosing alopecia (FFA), a condition characterized by progressive hairline recession, and its association with yellow facial papules. Histopathologic features of these papules included perifollicular inflammation, changes in elastic fibers, and sebaceous gland involvement. A proof-of-concept study demonstrated that oral isotretinoin effectively treated these facial papules in FFA patients. This finding was significant as it expanded the understanding of FFA's clinical manifestations and provided a potential therapeutic option.
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