Guidelines for Clinical Trials of Frontal Fibrosing Alopecia: Consensus Recommendations from the International FFA Cooperative Group

    June 2021 in “ British journal of dermatology/British journal of dermatology, Supplement ”
    Elise A. Olsen, Matthew Harries, Antonella Tosti, Wilma F. Bergfeld, Ulrike Blume-Peytavi, Valerie D. Callender, Vasiliki Chasapi, Osvaldo Correia, George Cotsarelis, Rachita Dhurat, Ncoza C. Dlova, Isabella Doche, Nkechi Anne Enechukwu, Ramón Grimalt, Satoshi Itami, Maria Hordinsky, Kuzma Кhobzei, W. S. Lee, Subrata Malakar, Andrew G. Messenger, Amy J. McMichael, Paradi Mirmirani, Yuliya Ovcharenko, Sofia Papanikou, Giselle Martins Pinto, Bianca Maria Piraccini, Rodrigo Pirmez, P. Reygagne, Janet L. Roberts, Lidia Rudnicka, David Saceda‐Corralo, Jerry Shapiro, Tatiana Silyuk, Rodney Sinclair, Rui Oliveira Soares, A. Souissi, Annika Vogt, Ken Washenik, Abraham Zlotogorski, Douglas Canfield, Sergio Vañó‐Galván
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    TLDR Experts agreed on guidelines to improve research on Frontal Fibrosing Alopecia.
    The document outlines consensus recommendations from the International FFA Cooperative Group (IFFACG) for clinical trials on Frontal Fibrosing Alopecia (FFA), aiming to standardize diagnostic criteria, severity rating, staging, and assessment methods. The IFFACG, comprising hair loss experts, achieved over 90% agreement on these guidelines to ensure consistent and meaningful data collection on FFA worldwide. This will enhance clinical and basic research on well-defined patient populations and facilitate the evaluation of treatment efficacy and safety. The guidelines introduce a Global Staging Score and the ALODEXFFA Score for simplified assessment of hair density and extent, which are expected to improve data aggregation and support further research to fill existing knowledge gaps about FFA.
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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

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      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

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