Lichen Planus Pigmentosus and Its Variants: Review and Update

    October 2017 in “ International Journal of Dermatology ”
    Juan Carlos Robles-Méndez, Paulina Rizo-Frías, Maira Elizabeth Herz‐Ruelas, Amit G. Pandya, Jorge Ocampo Candiani
    Image of study
    TLDR Lichen planus pigmentosus causes dark skin patches and is treated by avoiding triggers and using anti-inflammatory medications.
    Lichen planus pigmentosus (LPP) was a rare variant of lichen planus characterized by dark brown to gray pigmentation on sun-exposed areas, primarily affecting dark-skinned individuals. It involved an inflammatory response leading to pigmentary incontinence and was linked to factors like hepatitis C, sun exposure, and certain contactants. Variants included LPP-inversus, affecting flexural areas, and LPP along Blaschko's lines, associated with genetic mosaicisms. LPP could co-occur with other LP variants and autoimmune diseases. Treatment focused on avoiding triggers and using medications to reduce inflammation and pigmentation, thereby improving appearance and quality of life.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 41 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community I've tried everything and my hair is still thinning

      in Chat  6 upvotes 10 months ago
      The user has tried finasteride, oral minoxidil, iron supplements, vitamin D, and vitamin B12, but their hair is still thinning after 5 years. Another user suggested trying dutasteride.

      community Clascoterone (Winlevi) Update for Canada

      in Treatment  16 upvotes 2 years ago
      Clascoterone cream was submitted for review to Health Canada in August 2022, with hopes of approval within 3-6 months. It may potentially enhance finasteride's effects for hair loss treatment.

      community He used Dutasteride for 20 years. Interview

      in Treatment  108 upvotes 1 month ago
      Dutasteride has been used for 20 years with some hair thickness improvement but no dramatic regrowth. The user also experimented with minoxidil, tretinoin, and peptides like BPC 157 for potential benefits in hair density and quality.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 3 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

    Related Research

    1 / 1 results