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    Glossary Pigmentary Incontinence

    melanin leaks from damaged cells into surrounding tissue

    Pigmentary incontinence is a condition where melanin, the pigment responsible for skin and hair color, leaks out of damaged melanocytes (pigment-producing cells) and is taken up by macrophages (a type of immune cell) in the upper dermis. This process often results in areas of skin discoloration and can be seen in various skin disorders, such as lichen planus or vitiligo.

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      research Lichen planus pigmentosus and its variants: review and update

      94 citations , October 2017 in “International Journal of Dermatology”
      This narrative review discusses lichen planus pigmentosus, including its variations, associated triggers, and management strategies, but reports no new clinical results.

      research Miz1 is required for hair follicle structure and hair morphogenesis

      33 citations , July 2007 in “Journal of cell science”
      This study found that knocking out the transactivation domain of Miz1 in mouse keratinocytes disrupted hair follicle orientation, caused irregular pigmentation, and increased keratinocyte proliferation, indicating Miz1's role in hair follicle development and morphogenesis.

      research Ashy Dermatosis

      21 citations , November 1981 in “Archives of Dermatology”
      This study hypothesizes that postinflammatory hyperpigmentation in ashy dermatosis may result from basal cell apoptosis, as evidenced by consistent histologic findings across nine patients.