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    Glossary Pigmentary Incontinence

    melanin leaks from damaged cells into surrounding tissue

    Pigmentary incontinence is a condition where melanin, the pigment responsible for skin and hair color, leaks out of damaged melanocytes (pigment-producing cells) and is taken up by macrophages (a type of immune cell) in the upper dermis. This process often results in areas of skin discoloration and can be seen in various skin disorders, such as lichen planus or vitiligo.

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    1. Lichen planus pigmentosus and its variants: review and update International Journal of Dermatology · 2017 · 94 citations
    2. Miz1 is required for hair follicle structure and hair morphogenesis Journal of cell science · 2007 · 33 citations
    3. Ashy Dermatosis Archives of Dermatology · 1981 · 21 citations
    4. Diagnostic Usefulness of a Peribulbar Eosinophilic Infiltrate in Alopecia Areata JAMA Dermatology · 2014 · 19 citations
    5. A retrospective review of hyperaesthetic leucotrichia in horses in the USA Veterinary dermatology · 2016 · 2 citations
    6. Lichen Planus Pigmentosus in North Africa: A Series of 17 Cases Dermatology - Open Journal · 2019 · 4 citations
    7. Cutaneous Reactions to Drugs Elsevier eBooks · 2017 · 3 citations
    8. Pigmentary mosaicism: An update Indian Journal of Dermatology · 2008 · 7 citations
    9. Embryologic layers in dermatology: Developmental checkpoint disorders, diagnostic insight, and regenerative futures Italian Journal of Anatomy and Embryology · 2025
    10. Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders Frontiers in Immunology · 2020 · 20 citations
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