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GlossaryPigmentary Incontinence

melanin leaks from damaged cells into surrounding tissue

Pigmentary incontinence is a condition where melanin, the pigment responsible for skin and hair color, leaks out of damaged melanocytes (pigment-producing cells) and is taken up by macrophages (a type of immune cell) in the upper dermis. This process often results in areas of skin discoloration and can be seen in various skin disorders, such as lichen planus or vitiligo.

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research Lichen Planus Pigmentosus and Its Variants: Review and Update

94 citations , October 2017 in “International Journal of Dermatology”

Lichen planus pigmentosus causes dark skin patches and is treated by avoiding triggers and using anti-inflammatory medications.

research Miz1 Is Required for Hair Follicle Structure and Hair Morphogenesis

33 citations , July 2007 in “Journal of cell science”

Miz1 is essential for proper hair structure and growth.

research Ashy Dermatosis: Histologic Findings and Potential Associations

21 citations , November 1981 in “Archives of Dermatology”

Ashy dermatosis may be linked to atopy and thyroid disease and can be treated with topical steroids.

research Diagnostic Usefulness of a Peribulbar Eosinophilic Infiltrate in Alopecia Areata

19 citations , September 2014 in “JAMA Dermatology”

Eosinophilic infiltrate is not a reliable indicator for diagnosing chronic alopecia areata.

research A Retrospective Review of Hyperaesthetic Leucotrichia in Horses in the USA

2 citations , July 2016 in “Veterinary dermatology”

Hyperaesthetic leucotrichia in horses causes painful, recurring skin lesions and hair color changes, especially in Arabian and American paint horses.

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