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    GlossaryLichen Planus Pigmentosus

    chronic skin condition with dark, flat patches

    Lichen Planus Pigmentosus (LPP) is a chronic skin condition characterized by dark, flat patches on the skin, often appearing on sun-exposed areas and flexural regions like the armpits and groin. It is a variant of lichen planus, and while the exact cause is unknown, it is believed to be an autoimmune response where the body's immune system mistakenly attacks its own skin cells.

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      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  828 upvotes 5 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community I've tried everything and my hair is still thinning

      in Chat  6 upvotes 11 months ago
      The user has tried finasteride, oral minoxidil, iron supplements, vitamin D, and vitamin B12, but their hair is still thinning after 5 years. Another user suggested trying dutasteride.

      community Clascoterone (Winlevi) Update for Canada

      in Treatment  17 upvotes 2 years ago
      Clascoterone cream was submitted for review to Health Canada in August 2022, with hopes of approval within 3-6 months. It may potentially enhance finasteride's effects for hair loss treatment.
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      community He used Dutasteride for 20 years. Interview

      in Treatment  110 upvotes 2 months ago
      Dutasteride has been used for 20 years with some hair thickness improvement but no dramatic regrowth. The user also experimented with minoxidil, tretinoin, and peptides like BPC 157 for potential benefits in hair density and quality.

      community The Worst Hair Loss Condition You (MAY) have: LPP

      in Research/Science  43 upvotes 4 months ago
      Lichen Planopilaris (LPP) is an autoimmune condition causing permanent hair loss and fibrosis, often misdiagnosed. Treatments include pioglitazone, topical corticosteroids, anti-inflammatory medication, and Jak inhibitors.