Genetics of Alopecia
April 2012
in “
Encyclopedia of Life Sciences
”
alopecia areata CTLA4 IL-2 IL-22 HLA-class II UL16-binding protein-3 UL16-binding protein-6 syntaxin 17 IL-2RA peroxiredoxin 5 Eos androgenetic alopecia 5α-reductase isozymes androgen receptor ectodysplasin A2 receptor histone deacetylase 9 PAX1 FOXA2 congenital hypotrichosis EDA-A1 EDAR EDA-RADD p63 P-cadherin SPINK5 desmoglein 4 lipase H LIPH LPAR6 P2RY5 keratin 74 corneodesmosin APCDD hairless 5-alpha reductase
TLDR Different genes are linked to various types of hair loss.
The document "Genetics of Alopecia" from April 16, 2012, discussed the genetic factors associated with different types of alopecia. A genome-wide association study identified eight regions associated with alopecia areata (AA), including CTLA4, IL-2/IL-22, HLA-class II, UL16-binding protein-3 and -6, syntaxin 17, IL-2RA, peroxiredoxin 5 and Eos. Androgenetic alopecia was linked to both androgen-related genes (5α-reductase isozymes, androgen receptor, ectodysplasin A2 receptor, and histone deacetylase 9) and androgen-unrelated genes (PAX1 and FOXA2). The study also identified specific gene mutations associated with congenital hypotrichosis, including mutations in EDA-A1, EDAR, EDA-RADD, p63, P-cadherin, SPINK5, desmoglein 4, lipase H (LIPH), LPAR6 (P2RY5), keratin 74, corneodesmosin, APCDD, and hairless. These findings provided new insights into the pathogenesis of alopecia and the molecular mechanisms of normal hair growth.
