Search

for
Search:

GlossaryLymphoid Enhancer-Binding Factor 1 (LIPH)

protein regulating gene expression in immune cells and hair follicles

Lymphoid Enhancer-Binding Factor 1 (LEF1) is a protein that plays a crucial role in the regulation of gene expression, particularly in the development and function of immune cells and hair follicles. It is part of the Wnt signaling pathway, which is important for cell growth, differentiation, and tissue regeneration. In the context of hair biology, LEF1 is involved in the formation and cycling of hair follicles, and its dysregulation can contribute to conditions like alopecia.

Related Terms

Learn

0 / 0 results

— no results

Research

5 / 106 results

research Highly Prevalent LIPH Founder Mutations Causing Autosomal Recessive Woolly Hair/Hypotrichosis in Japan and the Genotype/Phenotype Correlations

15 citations, February 2014 in “PloS one”

LIPH mutations in Japan cause varying degrees of hair loss and woolly hair.

research In Silico Characterization and Analysis of Clinically Significant Variants of Lipase-H (LIPH Gene) Protein Associated with Hypotrichosis

May 2023 in “Pharmaceuticals”

Three specific mutations in the LIPH gene can cause hair loss by damaging the protein's structure and function.

research Botanical Extracts in Combination Improve Autosomal Recessive Woolly Hair/Hypotrichosis Caused by LIPH Mutations

March 2022 in “Journal of cosmetic dermatology”

Botanical extracts can help treat hair loss in people with certain genetic conditions.

Unexpectedly High Carrier Rates and Genotype/Phenotype Correlation: LIPH Mutations in Japanese Autosomal Recessive Woolly Hair/Hypotrichosis

research Unexpectedly High Carrier Rates and Genotype/Phenotype Correlation: LIPH Mutations in Japanese Autosomal Recessive Woolly Hair/Hypotrichosis

September 2016 in “Journal of Dermatological Science”

Certain gene mutations in Japanese people are linked to different types of hair loss, with some causing mild hair thinning and others leading to complete baldness.

research Clinicopathological Insights into the Phenotypic Variation of Autosomal Recessive Hypotrichosis/Wooly Hair by c.736T>A LIPH Mutation

September 2016 in “Journal of dermatological science”

The conclusion is that the variation in hair thinness in patients is mostly due to the amount of underdeveloped hairs, and treatments that thicken fine hairs might work for those with mild to severe conditions.

View more "liph" in research →

Community Join

0 / 0 results

— no results