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GlossaryLymphoid Enhancer-Binding Factor 1 (LIPH)

protein regulating gene expression in immune cells and hair follicles

Lymphoid Enhancer-Binding Factor 1 (LEF1) is a protein that plays a crucial role in the regulation of gene expression, particularly in the development and function of immune cells and hair follicles. It is part of the Wnt signaling pathway, which is important for cell growth, differentiation, and tissue regeneration. In the context of hair biology, LEF1 is involved in the formation and cycling of hair follicles, and its dysregulation can contribute to conditions like alopecia.

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research Highly Prevalent LIPH Founder Mutations Causing Autosomal Recessive Woolly Hair/Hypotrichosis in Japan and the Genotype/Phenotype Correlations

15 citations , February 2014 in “PloS one”

LIPH mutations in Japan cause varying degrees of hair loss and woolly hair.

research In Silico Characterization and Analysis of Clinically Significant Variants of Lipase-H (LIPH Gene) Protein Associated with Hypotrichosis

May 2023 in “Pharmaceuticals”

Three specific mutations in the LIPH gene can cause hair loss by damaging the protein's structure and function.

research Autosomal Recessive Woolly Hair/Hypotrichosis With Homozygous Mutation in the LIPH Gene: A Case Report

May 2025 in “Dermatology Reports”

A genetic mutation in the LIPH gene causes a rare hair disorder with sparse, curly hair.

Complete Defect in PA-PLA1α Secretion Function Leading to Autosomal Recessive Woolly Hair and Hypotrichosis: Insights from a Novel Compound Heterozygous LIPH Variant Study in a Chinese Pedigree

research Complete Defect in PA-PLA1α Secretion Function Leading to Autosomal Recessive Woolly Hair and Hypotrichosis: Insights from a Novel Compound Heterozygous LIPH Variant Study in a Chinese Pedigree

May 2025 in “Frontiers in Genetics”

A new genetic variant in the LIPH gene causes hair growth issues in a Chinese patient.

research Botanical Extracts in Combination Improve Autosomal Recessive Woolly Hair/Hypotrichosis Caused by LIPH Mutations

March 2022 in “Journal of cosmetic dermatology”

Botanical extracts can help treat hair loss in people with certain genetic conditions.

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in Satire 1977 upvotes 9 months ago

Hair loss treatments like finasteride, minoxidil, and ketoconazole shampoo are discussed humorously, with skepticism about future cures. Users express frustration over the lack of a permanent solution and joke about investing in stocks or using time travel to solve baldness.