Botanical Extracts in Combination Improve Autosomal Recessive Woolly Hair/Hypotrichosis Caused by LIPH Mutations

March 2022 in “ Journal of cosmetic dermatology ”

Baoquan Qu, Shengnan Meng, Chaowei Yang, Shuying Lv, Wenjun Lin, Dingquan Yang

botanical extracts autosomal recessive woolly hair hypotrichosis LIPH mutations hair growth prenatal diagnosis hair loss woolly hair

Studysummary In this case study, a 6-year-old child with autosomal recessive woolly hair showed significant hair growth and sustained improvement with a 4-year combination treatment of botanical extracts, though the precise mechanisms need further research.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

A study involving a 6-year-old female with autosomal recessive woolly hair (ARWH) caused by LIPH mutations demonstrated that a combined treatment of botanical extracts significantly improved hair growth. After 6 months, the patient's hair grew remarkably, and after 4 years, her hair remained dense. The study suggests that botanical extracts may offer a sustainable therapeutic effect for ARWH, although the specific mechanisms need further validation. The authors recommend considering regenerative strategies and prenatal diagnosis due to the significant impact of hair loss.

View this study on onlinelibrary.wiley.com →

Discuss this study in the Community →

Research cited in this study

9 / 9 results

A Randomized Blinded Retrospective Study: The Combined Use of Micro-Needling Technique, Low-Level Laser Therapy, and Autologous Non-Activated Platelet-Rich Plasma Improves Hair Re-Growth in Patients with Androgenic Alopecia

research A Randomized Blinded Retrospective Study: The Combined Use of Micro-Needling Technique, Low-Level Laser Therapy, and Autologous Non-Activated Platelet-Rich Plasma Improves Hair Re-Growth in Patients with Androgenic Alopecia

20 citations , July 2020 in “Expert Opinion on Biological Therapy”

This study found that combining micro-needling, low-level laser therapy, and autologous non-activated platelet-rich plasma increased hair density in patients with androgenic alopecia over the treatment period.

research Association of Topical Minoxidil With Autosomal Recessive Woolly Hair/Hypotrichosis Caused by LIPH Pathogenic Variants

5 citations , July 2020 in “JAMA Dermatology”

Minoxidil solution applied twice daily improved hair growth in patients with Woolly Hair/Hypotrichosis due to LIPH gene issues, with mild side effects.

Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

research Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy

65 citations , April 2020 in “International Journal of Molecular Sciences”

This review indicates that most studies reported positive effects of platelet-rich plasma injections for treating androgenic alopecia, with no major side effects, suggesting it may be a safe alternative to Minoxidil and Finasteride.

research Autologous Activated Platelet-Rich Plasma (AA-PRP) and Non-Activated (A-PRP) in Hair Growth: A Retrospective, Blinded, Randomized Evaluation in Androgenetic Alopecia

44 citations , February 2020 in “Expert Opinion on Biological Therapy”

In this study, autologous non-activated platelet-rich plasma was associated with greater hair re-growth than autologous activated platelet-rich plasma over long-term follow-up.

research Autologous Micrografts from Scalp Tissue: Trichoscopic and Long-Term Clinical Evaluation in Male and Female Androgenetic Alopecia

41 citations , January 2020 in “BioMed Research International”

This study found that micrografts containing human hair follicle mesenchymal stem cells significantly increased hair count and density compared to placebo over 58 weeks in patients experiencing hair loss.

research Assessment of a Bidirectional Association Between Major Depressive Disorder and Alopecia Areata

37 citations , January 2019 in “JAMA Dermatology”

This study found a bidirectional relationship between major depressive disorder and alopecia areata, with each condition significantly increasing the risk of subsequently developing the other.

research Topical Minoxidil Improves Congenital Hypotrichosis Caused by LIPH Mutations

7 citations , March 2015 in “British Journal of Dermatology”

Applying minoxidil can help improve hair growth in people with hair loss caused by LIPH gene mutations.

Total Glucosides of Paeony Capsule Plus Compound Glycyrrhizin Tablets for the Treatment of Severe Alopecia Areata in Children: A Randomized Controlled Trial

research Total Glucosides of Paeony Capsule Plus Compound Glycyrrhizin Tablets for the Treatment of Severe Alopecia Areata in Children: A Randomized Controlled Trial

20 citations , January 2013 in “Evidence-based complementary and alternative medicine”

This study found that TGPC plus CGT was more effective than CGT alone in reducing alopecia areata severity in children over 12 months, with similar safety profiles.

research Congenital Hair Loss Disorders: Rare, But Not Too Rare

41 citations , November 2011 in “The Journal of Dermatology”

This review identifies genetic mutations associated with congenital hair loss disorders in Japanese populations, particularly highlighting common LIPH gene mutations linked to woolly hair/hypotrichosis, and reports no new clinical results.