TLDR Applying minoxidil can help improve hair growth in people with hair loss caused by LIPH gene mutations.
In 2015, a study was conducted on four nonconsanguineous Japanese patients with autosomal recessive woolly hair/hypotrichosis (ARWH) caused by LIPH mutations. The patients, who used 1% or 5% topical minoxidil for 6 months to 3 years, showed hair growth after the application of the treatment. No adverse effects were reported. The LIPH gene plays a crucial role in hair growth in humans, and mutations in this gene are one cause of ARWH. The study concluded that topical minoxidil could be useful for treating congenital hypotrichosis caused by LIPH mutations. This conclusion was based on the observed improvement of hypotrichosis in five cases of ARWH due to LIPH mutations after the application of topical minoxidil.
15 citations,
February 2014 in “PloS one” LIPH mutations in Japan cause varying degrees of hair loss and woolly hair.
Minoxidil cream can safely treat hair loss in kids with ectodermal dysplasia.
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March 2012 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology” A specific gene mutation in Japanese people can cause varying degrees of hair thinning in adulthood.
58 citations,
January 2007 in “Dermatology” Minoxidil use in children may cause heart issues.
1 citations,
October 2022 in “PubMed” Patients generally have positive attitudes towards using topical Minoxidil for hair loss treatment.
5 citations,
July 2020 in “JAMA Dermatology” Minoxidil solution applied twice daily improved hair growth in patients with Woolly Hair/Hypotrichosis due to LIPH gene issues, with mild side effects.
April 2016 in “Journal of The American Academy of Dermatology” Alopecia areata affects quality of life more than androgenetic alopecia.
7 citations,
March 2015 in “British Journal of Dermatology” Applying minoxidil can help improve hair growth in people with hair loss caused by LIPH gene mutations.
8 citations,
July 2007 in “International Journal of Dermatology” Using 5% topical minoxidil improved and normalized the hair growth in a girl with short anagen hair naevus.
March 2005 in “Journal of The American Academy of Dermatology” Two cosmetic lotions improved hair growth and had better cosmetic effects than 2% minoxidil.
