Topical Minoxidil Improves Congenital Hypotrichosis Caused by LIPH Mutations

March 2015 in “ British Journal of Dermatology ”

Kana Tanahashi, Kazumitsu Sugiura, Masashi Akiyama

topical minoxidil congenital hypotrichosis LIPH mutations autosomal recessive woolly hair hair growth LIPH gene Rogaine

TLDR Applying minoxidil can help improve hair growth in people with hair loss caused by LIPH gene mutations.

In 2015, a study was conducted on four nonconsanguineous Japanese patients with autosomal recessive woolly hair/hypotrichosis (ARWH) caused by LIPH mutations. The patients, who used 1% or 5% topical minoxidil for 6 months to 3 years, showed hair growth after the application of the treatment. No adverse effects were reported. The LIPH gene plays a crucial role in hair growth in humans, and mutations in this gene are one cause of ARWH. The study concluded that topical minoxidil could be useful for treating congenital hypotrichosis caused by LIPH mutations. This conclusion was based on the observed improvement of hypotrichosis in five cases of ARWH due to LIPH mutations after the application of topical minoxidil.

View this study on academic.oup.com →

Discuss this study in the Community →

Research cited in this study

4 / 4 results

research Highly Prevalent LIPH Founder Mutations Causing Autosomal Recessive Woolly Hair/Hypotrichosis in Japan and the Genotype/Phenotype Correlations

15 citations, February 2014 in “PloS one”

LIPH mutations in Japan cause varying degrees of hair loss and woolly hair.

research Topical Minoxidil Treatment for Congenital Alopecia in Hypohidrotic Ectodermal Dysplasia

12 citations, March 2013

Minoxidil cream can safely treat hair loss in kids with ectodermal dysplasia.

research Prevalent Founder Mutation c.736T>A of LIPH in Autosomal Recessive Woolly Hair of Japanese Leads to Variable Severity of Hypotrichosis in Adulthood

12 citations, March 2012 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

A specific gene mutation in Japanese people can cause varying degrees of hair thinning in adulthood.

research Topical Use of Minoxidil in Children and Systemic Side Effects

58 citations, January 2007 in “Dermatology”

Minoxidil use in children may cause heart issues.

Related Community Posts Join

6 / 1000+ results

community drinking topical minoxidil – extreme hair growth everywhere

in Minoxidil 396 upvotes 2 years ago

At this point. In this conversation, users discussed the risks of drinking topical minoxidil and suggested alternative treatments such as obtaining a prescription for oral minoxidil or finasteride.

community Boys,Thank you all. almost 90days into treatment. dut/minox/ketoconazole shampoo

in Progress Pictures 83 upvotes 3 months ago

The user is using oral dutasteride, topical minoxidil (Regaine foam 5%), and ketoconazole shampoo for hair loss, reporting good results with no significant side effects. The user is 26 years old and applies minoxidil once or twice daily.

community Finasteride and Dutasteride results compilation thread

in Finasteride/Dutasteride 83 upvotes 4 months ago

Combining finasteride and dutasteride may enhance hair regrowth by targeting different enzymes, with positive results reported. Minoxidil, both oral and topical, is also used to improve effectiveness.

community I was on 2.5 mg oral minoxidil

in Progress Pictures 468 upvotes 8 months ago

User took 2.5 mg oral minoxidil, saw hair growth but stopped due to excessive body hair. Recently started finasteride and plans to update progress.

community Why I deleted my YouTube channel Part I

in Update 118 upvotes 3 years ago

A YouTuber named Kevin, also known as Rider_Of_Roach, who deleted his YouTube channel due to personal attacks and controversy surrounding his views on hair loss treatments. He advocated for FDA-approved treatments like finasteride and minoxidil but faced backlash from those who disagreed with him. The conversation also discusses his past trolling behavior and a lawsuit he filed against a website that published false information about him. Despite some disagreements, many viewers appreciated his research-based content and hope to see him return in the future.

community I will never more buy any hairloss traitements in public pharmacy

in Minoxidil 420 upvotes 4 months ago

A user was embarrassed by a pharmacist's loud mention of "minoxidil" for hair loss, sparking a discussion on the stigma and unprofessionalism. Users suggested online purchases or different pharmacies for privacy and reassured that most people don't notice others' purchases.

Related Research

6 / 6 results

research A Survey of Patient Attitudes Towards Topical Minoxidil in the Treatment of Hair Loss

1 citations, October 2022 in “PubMed”

Patients generally have positive attitudes towards using topical Minoxidil for hair loss treatment.

research Association of Topical Minoxidil With Autosomal Recessive Woolly Hair/Hypotrichosis Caused by LIPH Pathogenic Variants

5 citations, July 2020 in “JAMA Dermatology”

Minoxidil solution applied twice daily improved hair growth in patients with Woolly Hair/Hypotrichosis due to LIPH gene issues, with mild side effects.

Comparison of Quality of Life Using Hair-Specific Skindex-29 Between Androgenetic Alopecia and Alopecia Areata

research A Quantitative Hair Growth Assessment in Androgenetic Alopecia After Application of Two Cosmetic Lotions Versus 2% Topical Minoxidil

March 2005 in “Journal of The American Academy of Dermatology”

Two cosmetic lotions improved hair growth and had better cosmetic effects than 2% minoxidil.