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GlossaryLipase

enzyme that breaks down fats into fatty acids and glycerol

Lipase is an enzyme that plays a crucial role in the digestion of dietary fats. It breaks down triglycerides into free fatty acids and glycerol, making them easier for the body to absorb. This enzyme is produced primarily in the pancreas but is also found in the stomach and mouth.

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research In Silico Characterization and Analysis of Clinically Significant Variants of Lipase-H (LIPH Gene) Protein Associated with Hypotrichosis

May 2023 in “Pharmaceuticals”

Three specific mutations in the LIPH gene can cause hair loss by damaging the protein's structure and function.

research Identification of 736T>A Mutation of Lipase H in Japanese Siblings with Autosomal Recessive Woolly Hair

7 citations, February 2011 in “Journal of dermatology”

The 736T>A mutation in the LIPH gene is common in Japanese people with autosomal recessive woolly hair.

research Woolly Antics Between the Sheaths

1 citations, February 2009 in “Journal of Investigative Dermatology”

Lipase H is important for hair follicle function and shaping hair fibers.

research Molecular Basis of Hereditary Hair Diseases

January 2023 in “The Keio Journal of Medicine”

Certain gene variants can cause inherited hair diseases, which are important to diagnose and understand for patient care.

research Omega-6 Highly Unsaturated Fatty Acids in Leydig Cells Facilitate Male Sex Hormone Production

7 citations, September 2022 in “Communications biology”

Omega-6 fats in certain cells boost male hormone production.

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community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

in Research/Science 136 upvotes 7 months ago

The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.

community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance

in Research/Science 123 upvotes 11 months ago

The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.