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Glossary HLA Class I

proteins on cell surfaces presenting peptides to immune T cells

HLA Class I, also known as Human Leukocyte Antigen Class I, refers to a group of proteins found on the surface of almost all cells in the body. These proteins play a crucial role in the immune system by presenting fragments of proteins (peptides) from inside the cell to T cells, which helps the immune system recognize and respond to infected or abnormal cells, such as those infected by viruses or transformed into cancer cells.

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research Human Leukocyte Antigen Class II Alleles Are Associated with Risk of Alopecia Areata

36 citations , July 2007 in “Journal of Investigative Dermatology”

This study observed a strong negative association between the HLA-DQB1*0201 allele and the alopecia totalis/alopecia universalis phenotype in Caucasian individuals, indicating a potential protective role.

research Cell Surface B2m-Free Human Leukocyte Antigen (HLA) Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA?

3 citations , July 2023 in “Biomolecules”

This study reports that some human cell surface HLA-I molecules (including HLA-B27) can appear without their usual peptide component, potentially altering immune interactions, influencing arthritis development in specific mice models, and exhibiting upregulation in certain cancer cells.

research Alopecia areata update

391 citations , January 2010 in “Journal of The American Academy of Dermatology”

This article reviews the clinical presentation and histopathologic features of alopecia areata and proposes a hypothesis for its development, but it reports no new clinical results.

Alopecia Areata: Clinical Review and Treatment Approaches

research Alopecia Areata

50 citations , March 2000 in “American Journal of Clinical Dermatology”

This article discusses the etiology, clinical features, and treatment of alopecia areata but presents no new clinical findings, underlining the palliative nature of current therapies.

research Alopecia areata update

49 citations , April 2000 in “Journal of The American Academy of Dermatology”

This article discusses the etiology, clinical features, diagnosis, histopathology, and treatment of alopecia areata but reports no new clinical findings; it emphasizes the palliative nature of current treatments.

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