Cell Surface B2m-Free Human Leukocyte Antigen Monomers and Dimers: Are They Neo-HLA Class and Proto-HLA?

    July 2023 in “ Biomolecules ”
    Mepur H. Ravindranath, Narendranath M. Ravindranath, Senthamil R. Selvan … Edward J. Filippone
    Studysummary This study reports that some human cell surface HLA-I molecules (including HLA-B27) can appear without their usual peptide component, potentially altering immune interactions, influencing arthritis development in specific mice models, and exhibiting upregulation in certain cancer cells.
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