7 citations
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June 1976 in “JAMA” This study found that female patients with ankylosing spondylitis have a high association with the HLA-B27 antigen, similar to previous findings in males.
3 citations
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July 2023 in “Biomolecules” This study reports that some human cell surface HLA-I molecules (including HLA-B27) can appear without their usual peptide component, potentially altering immune interactions, influencing arthritis development in specific mice models, and exhibiting upregulation in certain cancer cells.
July 2016 in “Reumatología Clínica (English Edition)” This review discusses the wide range of physiologic skin changes during pregnancy and highlights less frequently recognized changes, based on literature from the past decade, without reporting new clinical results.
88 citations
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August 2019 in “Nature communications” In this study, researchers identified a specific T cell receptor associated with carbamazepine-induced severe cutaneous adverse reactions, demonstrating its potential for therapeutic development in patients with the HLA-B*15:02 genotype.
October 2024 in “International Journal of Research in Orthopaedics” This study found that adolescents carrying the HLA-B27 antigen who engaged in intense physical activity were more likely to develop ankylosing spondylitis, although not all predisposed individuals were affected, indicating other genetic and environmental factors might also play a role.