Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa

    August 2021 in “ Frontiers in medicine ”
    P. Rosa Coutinho Goulart Mariottoni, Simon W. Jiang, Courtney Ann Prestwood, Vaibhav Jain, Jutamas Suwanpradid, Melodi Javid Whitley, Margaret Coates, David Alan Brown, Detlev Erdmann, David L. Corcoran, Simon Gregory, Tarannum Jaleel, Jennifer Zhang, Tamia Harris-Tryon, Amanda S. MacLeod
    TLDR Immune cells in Hidradenitis suppurativa become more inflammatory and may be important for treatment targets.
    The study utilized single-cell RNA sequencing to investigate cellular and transcriptional changes in hidradenitis suppurativa (HS) lesions, focusing on M1 macrophage polarization. The findings revealed significant upregulation of genes related to pro-inflammatory and antimicrobial functions, such as phagocytosis and antibody-dependent cellular cytotoxicity, while genes associated with anti-inflammatory M2 macrophages were downregulated. This suggests that M1 macrophages play a crucial role in the chronic inflammation characteristic of HS. The study highlights potential therapeutic targets for managing HS by modulating macrophage activity and related inflammatory pathways.
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