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In this study published in Nature, researchers explored how hair follicle stem cells manage apoptotic cell clearance while maintaining their regenerative roles, identifying significant molecules involved in sensing and engulfing dying cells to sustain tissue health.

This study found that supraphysiological and physiological androgen levels inhibited U937 macrophages' phagocytosis of MRSA compared to untreated controls, but AR antagonism reversed this effect, suggesting targeting AR or using 5alpha-reductase inhibitors might aid bacterial clearance in elderly males' chronic wounds.

This study found that in vitro environments simulating testosterone levels in elderly males, testosterone and its metabolite DHT significantly reduced macrophages' ability to phagocytize MRSA and Pseudomonas aeruginosa, suggesting AR manipulation and inhibiting testosterone-DHT conversion might help fight wound infections in the elderly.

This study found that testosterone and its metabolite DHT reduced macrophage-mediated phagocytosis of bacteria like MRSA and P. aeruginosa in vitro, and blocking testosterone's conversion to DHT improved bacterial clearance, suggesting potential therapeutic strategies for combating wound infections in the elderly.