Stability of Polylactic Acid Particles and Release of Fluorochromes Upon Topical Application on Human Skin Explants

January 2012 in “ European journal of pharmaceutics and biopharmaceutics ”

Fiorenza Rancan, Antonia Todorova, Sabrina Hadam, Dimitrios Papakostas, Elsa Luciani, Christina Gräf, Ulrich Gernert, E. Rühl, Bernard Verrier, Wolfram Sterry, Ulrike Blume‐Peytavi, Annika Vogt

polylactic acid PLA particles hair follicles topical application fluorochromes lipophilicity aqueous dispersion skin surface physicochemical nature PLA HFs

TLDR PLA particles release their contents differently based on the type of fluorochrome used.

The study confirmed that polylactic acid (PLA) particles accumulated in hair follicles (HFs) after topical application, formed aggregates, and released incorporated substances. The stability of PLA particles, fluorochrome diffusion kinetics, and clearance were influenced by the lipophilicity of the incorporated fluorochromes. Despite being stable in aqueous dispersion, PLA particles lost their particulate morphology upon contact with the skin surface. This indicated that the physicochemical nature of the incorporated substances affected the stability and release behavior of PLA particles on the skin.

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