Stability of Polylactic Acid Particles and Release of Fluorochromes Upon Topical Application on Human Skin Explants

January 2012 in “ European journal of pharmaceutics and biopharmaceutics ”

Fiorenza Rancan, Antonia Todorova, Sabrina Hadam, Dimitrios Papakostas, Elsa Luciani, Christina Gräf, Ulrich Gernert, E. Rühl, Bernard Verrier, Wolfram Sterry, Ulrike Blume‐Peytavi, Annika Vogt

polylactic acid PLA particles hair follicles topical application fluorochromes lipophilicity aqueous dispersion skin surface physicochemical nature PLA HFs

TLDR PLA particles release their contents differently based on the type of fluorochrome used.

The study confirmed that polylactic acid (PLA) particles accumulated in hair follicles (HFs) after topical application, formed aggregates, and released incorporated substances. The stability of PLA particles, fluorochrome diffusion kinetics, and clearance were influenced by the lipophilicity of the incorporated fluorochromes. Despite being stable in aqueous dispersion, PLA particles lost their particulate morphology upon contact with the skin surface. This indicated that the physicochemical nature of the incorporated substances affected the stability and release behavior of PLA particles on the skin.

View this study on sciencedirect.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells by Hair Follicles and Their Transport in Mice

119 citations, December 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Nanoparticles can deliver vaccines through hair follicles, triggering immune responses and providing protection.

research 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin

323 citations, April 2006 in “The journal of investigative dermatology/Journal of investigative dermatology”

Only 40 nm nanoparticles can enter skin cells effectively for potential vaccine delivery.

research Penetration Profile of Microspheres in Follicular Targeting of Terminal Hair Follicles

316 citations, June 2004 in “The journal of investigative dermatology/Journal of investigative dermatology”

Microspheres about 1.5 micrometers in size can best penetrate hair follicles, potentially reaching important stem cells.

Similar Research

5 / 298 results

research Hair Follicle Targeting with Nanoparticles

5 citations, September 2012 in “Springer eBooks”

Nanoparticles can be used to deliver drugs to hair follicles, potentially improving treatments for conditions like acne and alopecia, and could also be used for vaccine delivery and gene therapy.

research Delivery and Targeting of Nanoparticles into Hair Follicles

94 citations, September 2014 in “Therapeutic Delivery”

Nanoparticles can improve skin treatments by better targeting hair follicles, but more research is needed for advancement.

research Nanostructured Drug Delivery Systems for Targeting 5-Alpha-Reductase Inhibitors to the Hair Follicle

3 citations, January 2022 in “Pharmaceutics”

Nanostructured delivery systems could potentially improve hair loss treatment by targeting drugs to hair follicles, reducing side effects and dosage, but the best size, charge, and materials for these systems need further investigation.

The Impact of Particle Size of Nanostructured Lipid Carriers on Follicular Drug Delivery: A Comprehensive Analysis of Mouse and Human Hair Follicle Penetration

research The Impact of Particle Size of Nanostructured Lipid Carriers on Follicular Drug Delivery: A Comprehensive Analysis of Mouse and Human Hair Follicle Penetration

March 2024 in “Bioimpacts”

400 nm particles penetrate hair follicles best, but mouse models aren't fully reliable for human studies.

research Targeted Delivery of a Poorly Water-Soluble Compound to Hair Follicles Using Polymeric Nanoparticle Suspensions

25 citations, June 2011 in “International journal of pharmaceutics”

Nanoparticles effectively deliver water-insoluble drugs to hair follicles, stimulating hair growth without irritating the skin.